Title:Antimycotic Drugs and their Mechanisms of Resistance to Candida Species
Volume: 23
Issue: 2
关键词:
念珠菌血症、医院感染、唑类耐药、多烯耐药、棘白菌素耐药、抗真菌药物
摘要: Fungal infections have shown an upsurge in recent decades, which is mainly because of
the increasing number of immunocompromised patients and the occurrence of invasive candidiasis
has been found to be 7-15 fold greater than that of invasive aspergillosis. The genus Candida comprises
more than 150 distinct species, however, only a few of them are found to be pathogenic to
humans. Mortality rates of Candida species are found to be around 45% and the reasons for this intensified
mortality are inefficient diagnostic techniques and unfitting initial treatment strategies.
There are only a few antifungal drug classes that are employed for the remedy of invasive fungal infections.
which include azoles, polyenes, echinocandins, and pyrimidine analogs. During the last
2-3 decades, the usage of antifungal drugs has increased several folds due to which the reports of
escalating antifungal drug resistance have also been recorded. The resistance is mostly to the triazole-
based compounds. Due to the occurrence of antifungal drug resistance, the success rates of
treatment have been reduced as well as major changes have been observed in the frequency of fungal
infections. In this review, we have summarized the major molecular mechanisms for the development
of antifungal drug resistance.
