Title:Recent Advances in the Synthesis of Tacrine Derivatives as Multifunctional Agents for Alzheimer's Disease
Volume: 25
Issue: 21
Author(s): Ikram Baba Ahmed, Zahira Kibou*Noureddine Choukchou-Braham
Affiliation:
- Laboratoire de Catalyse et Synthese en Chimie Organique, Faculte des Sciences, Universite de Tlemcen, BP 119, 13000 Tlemcen,Algeria
Keywords:
Tacrine, tetrahydroacridine, Friedländer reaction, Tacrine homo- and heterodimers, cholinesterase inhibitors, multi-targetdirected
ligands (MTDLs), Alzheimer's disease, hepatotoxicity.
Abstract: Alzheimer’s is a neurodegenerative pathology. The first therapeutic strategy for the
treatment of AD was mainly acetylcholinesterase inhibitors (AChEIs) such as Tacrine; a linear
tricyclic compound that occupies an important place in the treatment of this disease with
its properties pharmacophore. In this regard, the development of tacrine-analogs more efficient
and safe with new measures and investigations has drawn immense attention. Various
structural modifications of Tacrine have been carried out on different parts. Mainly some
modification in the ring structure of tacrine or by connecting the amino group with different
hybrids based on natural or synthetic compounds and drugs already in existence. These
tacrine congeners have considerable potential for the development of new drugs for the treatment
of Alzheimer's disease. Therefore, this review presents an overview of the most important
structural modifications in tacrine rings based on the current trends reported in recent decades towards the use of
natural products and synthetic analogs as a source of new anti-Alzheimer drugs.