Title:MicroRNAs Involved in Oxidative Stress Processes Regulating Physiological
and Pathological Responses
Volume: 10
Issue: 3
Author(s): Yongjie Xu, Xunhe Huang, Qingbin Luo*Xiquan Zhang*
Affiliation:
- Department of Animal Genetics, Breeding and Reproduction, College of Animal Science/ Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642,China
- Department of Animal Genetics, Breeding and Reproduction, College of Animal Science/ Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642,China
Keywords:
microRNA, oxidative stress, ROS, keap1-Nrf2 pathway, antioxidant genes, physiological and pathological responses
Abstract: Oxidative stress influences several physiological and pathological cellular events, including
cell differentiation, excessive growth, proliferation, apoptosis, and inflammatory response.
Therefore, oxidative stress is involved in the pathogenesis of various diseases, including pulmonary
fibrosis, epilepsy, hypertension, atherosclerosis, Parkinson’s disease, cardiovascular disease,
and Alzheimer’s disease. Recent studies have shown that several microRNAs (miRNAs) are involved
in the development of various diseases caused by oxidative stress and that miRNAs may be
useful to determine the inflammatory characteristics of immune responses during infection and disease.
In this review, we describe the known effects of miRNAs on reactive oxygen species to induce
oxidative stress and miRNA regulatory mechanisms involved in the uncoupling of Keap1-Nrf2
complexes. Finally, we summarized the functions of miRNAs in several antioxidant genes. Understanding
the crosstalk between miRNAs and oxidative stress-inducing factors during physiological
and pathological cellular events may have implications for the design of more effective treatments
for immune diseases.
