Title:Transcription Factors in Deriving β Cell Regeneration: A Potential
Novel Therapeutic Target
Volume: 22
Issue: 5
关键词:
再生，胰腺干细胞，转录因子，胰腺生理病理学，β细胞，转分化，重编程，细胞可塑性，胰岛素，内胚层，Pdx1/NEUROG3/MaFA。
摘要: Recently, remarkable advances have been achieved in the molecular
biopathology field and researchers turned to evaluate the role, molecular mechanisms,
and clinical value of transcription factors in curing a variety of parenchymal degenerative
pathologies. Special agents have the capability to cell lineage reprogramming termed
transcription factors with a capacity for gene expression modification. Therefore,
whatever niche factor may modify gene expression is termed as a transcription factor. A
variety of transcription factors have been identified to participate in the regulation of
pancreatic stem cell maturation, differentiation, and proliferation; primarily, not only
Pdx1, NeuroG3, and MafA, but transcription factors can also transdifferentiate somatic
cells in between, liver and gallbladder cells into insulin-producing cells. These
heterogenic capabilities of the transcription factors are of clinical significance since they
can control cells' regeneration capacity. Physiologically, the pancreatic cells are
subdivided into exocrine and endocrine cells. Pancreatic endocrine dysfunction is
clinically more common and of more clinical relevance. The paper will illustrate the role
and possible mechanisms of transcription factors in the transdifferentiation of endodermderived
somatic cells into pancreatic beta-like cells. Clinically, understanding the
potential mechanisms in generating physiologic beta cells is extremely crucial to
optimize current therapies and evaluate new therapeutic targets via recruiting specific
transcription factors. The transcription factors can be applied to both types of diabetes
and chronic pancreatitis.
