Title:Insights into the Mechanism of the Therapeutic Potential of Herbal
Monoamine Oxidase Inhibitors in Neurological Diseases
Volume: 23
Issue: 3
关键词:
黄素酶、单胺氧化酶抑制剂、细胞凋亡、神经系统疾病、阿尔茨海默病、帕金森病、氧化应激
摘要: Monoamine oxidase (MAO) is an enzyme that catalyzes the deamination of
monoamines and other proteins. MAO’s hyperactivation results in the massive generation of reactive
oxygen species, which leads to a variety of neurological diseases such as Alzheimer's disease,
Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and depression-like disorders.
Although synthetic MAO inhibitors are clinically available, they are associated with side effects
such as hepatotoxicity, cheese reaction, hypertensive crisis, and so on, necessitating the investigation
of alternative MAO inhibitors from a natural source with a safe profile. Herbal medications
have a significant impact on the prevention of many diseases; additionally, they have fewer
side effects and serve as a precursor for drug development. This review discusses the potential of
herbal MAO inhibitors as well as their associated mechanism of action, with an aim to foster future
research on herbal MAO inhibitors as a potential treatment for neurological diseases.