Title:Synthetic Aspects of Condensed Pyrimidine Derivatives
Volume: 25
Issue: 21
Author(s): Meenu Devi*, Shivangi Jaiswal, Jaya Dwivedi and Navjeet Kaur*
Affiliation:
- Department of Chemistry, Banasthali Vidyapith, Banasthali-304022, Rajasthan,India
- Department of Chemistry, Banasthali Vidyapith, Banasthali-304022, Rajasthan,India
Keywords:
Heterocycles, pyrimidine, nitrogen, metal, ionic-liquid, microwave, solid-phase.
Abstract: The present review focuses on the synthesis of two heteroatoms containing sixmembered
heterocyclic compounds, i.e., pyrimidine. In this review, a number of pyrimidine
derivatives have been illustrated, which show the exceptional ability towards clinical practices.
Pyrimidine derivatives show antimicrobial, antibacterial, antifungal, antiallergic, antiinflammatory,
anticancer, and anticonvulsant activities. Therefore, researchers are encouraged to
synthesize novel, potent, safe, and selective pyrimidine derivatives that are effective against
the mutant strains, and the development of synthetic protocols is a high priority in medicinal
chemistry research. Many methodologies have been developed for the preparation of pyrimidine
derivatives. In this review article, the synthetic strategies of pyrimidine derivatives are
classified into metal-catalyzed synthesis, ionic-liquid assisted synthesis, microwave-assisted
synthesis, and solid-phase synthesis.