Title:The Link between Exercise and Homocysteine in the Alzheimer’s Disease: A Bioinformatic Network Model
Volume: 20
Issue: 9
Author(s): Luana Lemos Leão, Laís Francielle Francisca Felício, Knut Engedal, Gro Gujord Tangen, Kari Midtbø Kristiansen, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula and Renato Sobral Monteiro-Junior*
Affiliation:
- Graduate Program of Health Sciences, State University of Montes Claros, Montes Claros, Minas Gerais,Brazil
Keywords:
Gene interaction network, Alzheimer's disease, homocysteine, exercise, oxidative stress, nitric oxide, HHcy.
Abstract: Elevated peripheral expression of homocysteine (Hcy) is associated with an increased
risk of coronary heart disease and stroke, diabetes, and cancer. It is also associated with cognitive
impairment as it has been reported that high levels of Hcy cause cognitive dysfunction and memory
deficit. Among several etiological factors that contribute to the pathogenesis of neurodegenerative
diseases, including Alzheimer’s disease (AD), Hcy seems to directly contribute to the generation
of neurotoxicity factors. This study aims to hypothesize the molecular mechanism by which exercise
can reduce the risk of neurological complications promoted by hyperhomocysteinemia (HHcy),
and discuss how exercise could reduce the risk of developing AD by using bioinformatics network
models. According to the genes network, there are connections between proteins and amino
acids associated with Hcy, exercise, and AD. Studies have evidenced that exercise may be one of
several processes by which acid nitric availability can be maximized in the human body, which is
particularly important in reducing cell loss and tau pathology and, thereby, leading to a reduced
risk of complications associated with HHcy and AD.
