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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Lipid Nanocarriers for Neurotherapeutics: Introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches

Author(s): Mohammed Aslam, Md. Noushad Javed*, Hala Hasan Deeb, Michel Kaisar Nicola, Mohd. Aamir Mirza, Md. Sabir Alam, Md. Habban Akhtar and Aafrin Waziri

Volume 21, Issue 10, 2022

Published on: 06 July, 2021

Page: [952 - 965] Pages: 14

DOI: 10.2174/1871527320666210706104240

Price: $65

Abstract

Significant efforts have been made in research to discover newer neurotherapeutics, however, the rate of reported neurological disorders has been increasing at an alarming speed. Neurotherapeutics delivery in the brain is still posing a significant challenge, owing to the blood-brain barrier and blood-cerebrospinal fluid barrier. These physiological barriers restrict the passage of systemically available fractions of neurotherapeutics into the brain, owing to low permeability and drug localization factors. Neurotherapeutics encapsulating lipid carriers favor a significant increase in bioavailability of poorly water-soluble drugs by enhancing solubility in the gastrointestinal tract and favoring stability. Due to their small size and lipid-based composition, these carriers offer enhanced permeability across the semi-permeable blood-brain barrier to effectively transport encapsulated loads, such as synthetic drugs, nutraceuticals, phytoconstituents, herbal extracts, and peptides, thereby reducing incidences of off-target mediated adverse impacts and toxicity. The most significant advantage of such lipid-based delivery systems is non–invasive nature and targeting of neurotherapeutics to the central nervous system. Critical attributes of lipid-based carriers modulate release rates in rate-controlled manners, enable higher penetration through the blood-brain barrier, and bypass the hepatic first-pass metabolism leading to higher CNS bioavailability neurotherapeutics.

The current review discusses a brief and introductory account of the limitations of neurotherapeutics, pharmacological barriers, challenges in brain-targeted delivery, and the potential of nanotechnology- processed lipid-based carriers in the clinical management of neuronal disorders.

Keywords: Nanotechnology, drug delivery, nutraceuticals, nanoparticles, nanoemulsion, challenges, toxicity, regulatory, patents, liposomes, polymers.

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[1]
Pottoo FH, Tabassum N, Javed MN, et al. Raloxifene potentiates the effect of fluoxetine against maximal electroshock induced seizures in mice. Eur J Pharm Sci 2020; 146: 105261.
[http://dx.doi.org/10.1016/j.ejps.2020.105261] [PMID: 32061655]
[2]
Pardridge, WM Brain drug targeting: The future of brain drug development. J Clin Pathol 2002; 55(2): 158.
[3]
Pandey M, Saleem S, Nautiyal H, Pottoo FH, Javed MN. PINK1/parkin in neurodegenerative disorders: Crosstalk between mitochondrial stress and neurodegeneration.Quality control of cellular protein in neurodegenerative disorders. IGI Global 2020; pp. 282-301.
[http://dx.doi.org/10.4018/978-1-7998-1317-0.ch011]
[4]
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001; 46(1-3): 3-26.
[http://dx.doi.org/10.1016/S0169-409X(00)00129-0] [PMID: 11259830]
[5]
Sharma P, Denny WA, Garg S. Effect of wet milling process on the solid state of indomethacin and simvastatin. Int J Pharm 2009; 380(1-2): 40-8.
[http://dx.doi.org/10.1016/j.ijpharm.2009.06.029] [PMID: 19576976]
[6]
Kakran M, Sahoo NG, Li L, et al. Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension. Int J Pharm 2010; 383(1-2): 285-92.
[http://dx.doi.org/10.1016/j.ijpharm.2009.09.030] [PMID: 19781606]
[7]
Pottoo FH, Tabassum N, Javed MN, et al. The synergistic effect of raloxifene, fluoxetine, and bromocriptine protects against pilocarpine-induced status epilepticus and temporal lobe epilepsy. Mol Neurobiol 2019; 56(2): 1233-47.
[http://dx.doi.org/10.1007/s12035-018-1121-x] [PMID: 29881945]
[8]
Javed MN, Kohli K, Amin S. Risk assessment integrated QbD approach for development of optimized bicontinuous mucoadhesive limicubes for oral delivery of rosuvastatin. AAPS PharmSciTech 2018; 19(3): 1377-91.
[http://dx.doi.org/10.1208/s12249-018-0951-1] [PMID: 29388027]
[9]
Patwekar SL, Baramade MK. Controlled release approach to novel multiparticulate drug delivery system. Int J Pharm Pharm Sci 2012; 4(3): 757-63.
[10]
Jain N, Jain R, Thakur N, et al. Nanotechnology: A safe and effective drug delivery system. Asian J Pharmaceut Clin Res 2010; 3(3): 159-65.
[11]
Alam S, Aslam M, Khan A, et al. Nanostructured lipid carriers of pioglitazone for transdermal application: From experimental design to bioactivity detail. Drug Deliv 2016; 23(2): 601-9.
[http://dx.doi.org/10.3109/10717544.2014.923958] [PMID: 24937378]
[12]
Safari J, Zarnegar Z. Advanced drug delivery systems: Nanotechnology of health design A review. J Saudi Chem Soc 2014; 18(2): 85-99.
[http://dx.doi.org/10.1016/j.jscs.2012.12.009]
[13]
Kalepu S, Nekkanti V. Insoluble drug delivery strategies: Review of recent advances and business prospects. Acta Pharm Sin B 2015; 5(5): 442-53.
[http://dx.doi.org/10.1016/j.apsb.2015.07.003] [PMID: 26579474]
[14]
Rangasamy M, Parthiban KG. Recent advances in novel drug delivery systems. Int J Res Ayurveda Pharm 2010; 1(2): 316-26.
[15]
Neuwelt EA, Bauer B, Fahlke C, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci 2011; 12(3): 169-82.
[http://dx.doi.org/10.1038/nrn2995] [PMID: 21331083]
[16]
Wong HL, Wu XY, Bendayan R. Nanotechnological advances for the delivery of CNS therapeutics. Adv Drug Deliv Rev 2012; 64(7): 686-700.
[http://dx.doi.org/10.1016/j.addr.2011.10.007] [PMID: 22100125]
[17]
Vlieghe P, Khrestchatisky M. Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery. Med Res Rev 2013; 33(3): 457-516.
[http://dx.doi.org/10.1002/med.21252] [PMID: 22434495]
[18]
Pottoo FH, Sharma S, Javed MN, et al. Lipid-based nanoformulations in the treatment of neurological disorders. Drug Metab Rev 2020; 52(1): 185-204.
[http://dx.doi.org/10.1080/03602532.2020.1726942] [PMID: 32116044]
[19]
Bennewitz MF, Saltzman WM. Nanotechnology for delivery of drugs to the brain for epilepsy. Neurotherapeutics 2009; 6(2): 323-36.
[http://dx.doi.org/10.1016/j.nurt.2009.01.018] [PMID: 19332327]
[20]
Jahangir MA, Gilani SJ, Muheem A, et al. Quantum dots: Next generation of smart nano-systems. Pharm Nanotechnol 2019; 7(3): 234-45.
[http://dx.doi.org/10.2174/2211738507666190429113906] [PMID: 31486752]
[21]
Barnett GH, Ed. High-grade gliomas: Diagnosis and treatment. Germany: Springer Science Business Media 2007.
[http://dx.doi.org/10.1007/978-1-59745-185-7]
[22]
Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7(1): 41-53.
[http://dx.doi.org/10.1038/nrn1824] [PMID: 16371949]
[23]
Müller RH. Colloidal carriers for controlled drug delivery and targeting: Modification, characterization and in vivo distribution. UK: Taylor & Francis 1991.
[24]
Fisher RS, Ho J. Potential new methods for antiepileptic drug delivery. CNS Drugs 2002; 16(9): 579-93.
[http://dx.doi.org/10.2165/00023210-200216090-00001] [PMID: 12153331]
[25]
Reddy K, Reddy V, Loya PC. Molecular aspects of BBB. Res J Pharm Dos Forms Technol 2014; 6(2): 105-9.
[26]
Micheli MR, Bova R, Magini A, Polidoro M, Emiliani C. Lipid-based nanocarriers for CNS-targeted drug delivery. Recent Patents CNS Drug Discov 2012; 7(1): 71-86.
[http://dx.doi.org/10.2174/157488912798842241] [PMID: 22283231]
[27]
Nabi B, Rehman S, Pottoo FH, Baboota S, Ali J. Dissecting the therapeutic relevance of gene therapy in NeuroAIDS, an evolving epidemic. Curr Gene Ther 2020; 20(3): 174-83.
[http://dx.doi.org/10.2174/1566523220666200615151805] [PMID: 32538727]
[28]
Javed MN, Alam MS, Waziri A, et al. QbD applications for the development of nanopharmaceutical products. pharmaceutical quality by design. USA: Academic Press 2019; pp. 229-53.
[http://dx.doi.org/10.1016/B978-0-12-815799-2.00013-7]
[29]
Thrall JH. Nanotechnology and medicine. Radiology 2004; 230(2): 315-8.
[http://dx.doi.org/10.1148/radiol.2302031698] [PMID: 14752175]
[30]
Sharma S, Javed MN, Pottoo FH, et al. Bioresponse inspired nanomaterials for targeted drug and gene delivery. Pharm Nanotechnol 2019; 7(3): 220-33.
[http://dx.doi.org/10.2174/2211738507666190429103814] [PMID: 31486751]
[31]
Binnig G, Rohrer H. Scanning tunneling microscopy. Surf Sci 1983; 126(1-3): 236-44.
[http://dx.doi.org/10.1016/0039-6028(83)90716-1]
[32]
Allaf AW, Kroto HW, Balm SP. C 60: Buckminster fullerene. 1994; pp. 19-53.
[33]
Kalinin SV, Rodriguez BJ, Jesse S, et al. Nanoscale electromechanics of ferroelectric and biological systems: A new dimension in scanning probe microscopy. Annu Rev Mater Res 2007; 37: 189-238.
[http://dx.doi.org/10.1146/annurev.matsci.37.052506.084323]
[34]
Mishra S, Sharma S, Javed MN, et al. Bioinspirednanocomposites: Applications in disease diagnosis and treatment. Pharm Nanotechnol 2019; 7(3): 206-19.
[http://dx.doi.org/10.2174/2211738507666190425121509] [PMID: 31030662]
[35]
Alam MS, Javed MN, Pottoo FH, et al. QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye. Appl Organomet Chem 2019; 33(9): e5071.
[http://dx.doi.org/10.1002/aoc.5071]
[36]
Sahoo SK, Parveen S, Panda JJ. The present and future of nanotechnology in human health care. Nanomedicine (Lond) 2007; 3(1): 20-31.
[http://dx.doi.org/10.1016/j.nano.2006.11.008] [PMID: 17379166]
[37]
Pottoo FH, Barkat MA, Ansari MA, Javed MN, Jamal QM, Kamal MA. Nanotechnologoical based miRNA intervention in the therapeutic management of neuroblastoma. Semin Cancer Biol 2021; 69: 100-8.
[http://dx.doi.org/10.1016/j.semcancer.2019a.09.017]
[38]
Hasnain MS, Javed MN, Alam MS, et al. Purple heart plant leaves extract-mediated silver nanoparticle synthesis: Optimization by Box-Behnken design. Mater Sci Eng C 2019; 99: 1105-14.
[http://dx.doi.org/10.1016/j.msec.2019.02.061] [PMID: 30889643]
[39]
National nanotechnology initiative. Available from: www.nano.gov
[40]
Ratner M, Ratner D. Size matters. Nanotechnology.Upper Saddle River, NJ: Prentice Hall 2003; pp. 11-8.
[41]
Alam MS, Garg A, Pottoo FH, et al. Gum ghatti mediated, one pot green synthesis of optimized gold nanoparticles: Investigation of process-variables im-pact using Box-Behnken based statistical design. Int J Biol Macromol 2017; 104(Pt A): 758-67.
[42]
De Heer WA, Chatelain A, Ugarte D. A carbon nanotube field-emission electron source. Science 1995; 270(5239): 1179-80.
[43]
Franklin AD, Luisier M, Han SJ, et al. Sub-10 nm carbon nanotube transistor. Nano Lett 2012; 12(2): 758-62.
[http://dx.doi.org/10.1021/nl203701g] [PMID: 22260387]
[44]
Nasrollahzadeh M, Sajadi SM, Sajjadi M, Issaabadi Z. An introduction to nanotechnology. Interface Sci Technol 2019; 28: 1-27.
[45]
Aslam M, Imam SS, Aqil M, Sultana Y, Ali A. Levofloxacin loaded gelrite-cellulose polymer based sustained ocular drug delivery: Formulation, optimization and biological study. J Polymer Eng 2016; 36(8): 761-9.
[http://dx.doi.org/10.1515/polyeng-2015-0218]
[46]
Aslam M, Aqil M, Ahad A, Najmi AK, Sultana Y, Ali A. Application of box–behnken design for preparation of glibenclamide loaded lipid based nanoparticles: Optimization, in in vitro skin permeation, drug release and in vivo pharmacokinetic study. J Mol Liq 2016; 219: 897-908.
[http://dx.doi.org/10.1016/j.molliq.2016.03.069]
[47]
Freitas RA. Molecular transport and sortation. Nanomedicine. Austin, Tex: Landes Bioscience 1999; pp. 71-92.
[48]
Freitas RA. Navigation. Nanomedicine. Austin, Tex: Landes Bioscience 1999; pp. 209-74.
[49]
Roco MC, Williams RS, Alivisatos P, Eds. Nanotechnology research directions: IWGN workshop report: Vision for nanotechnology in the next decade. Germany: Springer Science & Business Media 2000.
[http://dx.doi.org/10.1007/978-94-015-9576-6]
[50]
Lü JM, Wang X, Marin-Muller C, et al. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn 2009; 9(4): 325-41.
[http://dx.doi.org/10.1586/erm.09.15] [PMID: 19435455]
[51]
Wei H, Wang E. Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes. Chem Soc Rev 2013; 42(14): 6060-93.
[http://dx.doi.org/10.1039/c3cs35486e] [PMID: 23740388]
[52]
Hauck TS, Giri S, Gao Y, Chan WC. Nanotechnology diagnostics for infectious diseases prevalent in developing countries. Adv Drug Deliv Rev 2010; 62(4-5): 438-48.
[http://dx.doi.org/10.1016/j.addr.2009.11.015] [PMID: 19931580]
[53]
Crommelin DJ, Storm G, Jiskoot W, Stenekes R, Mastrobattista E, Hennink WE. Nanotechnological approaches for the delivery of macromolecules. J Control Release 2003; 87(1-3): 81-8.
[http://dx.doi.org/10.1016/S0168-3659(03)00014-2] [PMID: 12618025]
[54]
Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 2012; 64: 24-36.
[http://dx.doi.org/10.1016/j.addr.2012.09.006] [PMID: 12204596]
[55]
Roy I, Ohulchanskyy TY, Pudavar HE, et al. Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: A novel drug-carrier system for photodynamic therapy. J Am Chem Soc 2003; 125(26): 7860-5.
[http://dx.doi.org/10.1021/ja0343095] [PMID: 12823004]
[56]
Pottoo FH, Javed MN, Barkat MA, et al. Estrogen and serotonin: Complexity of interactions and implications for epileptic seizures and epileptogenesis. Curr Neuropharmacol 2019; 17(3): 214-31.
[http://dx.doi.org/10.2174/1570159X16666180628164432] [PMID: 29956631]
[57]
Nigar S, Pottoo FH, Tabassum N, Verma SK, Javed MN. Molecular insights into the role of inflammation and oxidative stress in epilepsy. J Adv Med Pharmaceut Sci 2016; 10(1): 1-9.
[http://dx.doi.org/10.9734/JAMPS/2016/24441]
[58]
Baig MS, Ahad A, Aslam M, Imam SS, Aqil M, Ali A. Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in in vitro release, ocular tolerance, and antibacterial activity. Int J Biol Macromol 2016; 85: 258-70.
[http://dx.doi.org/10.1016/j.ijbiomac.2015.12.077] [PMID: 26740466]
[59]
Emerich DF. Nanomedicine–prospective therapeutic and diagnostic applications. Expert Opin Biol Ther 2005; 5(1): 1-5.
[http://dx.doi.org/10.1517/14712598.5.1.1]
[60]
Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007; 4(4): 403-16.
[http://dx.doi.org/10.1517/17425247.4.4.403] [PMID: 17683253]
[61]
Torchilin VP. Multifunctional nanocarriers. Adv Drug Deliv Rev 2006; 58(14): 1532-55.
[http://dx.doi.org/10.1016/j.addr.2006.09.009] [PMID: 17092599]
[62]
Fahmy TM, Fong PM, Goyal A, Saltzman WM. Targeted for Drug Delivery. Nanotoday. Fahr A. and Liu X.(2007). Drug delivery strategies for poorly watersoluble drugs. Expert Opin Drug Deliv 2005; 4: 403-16.
[63]
Sachdeva MS. Drug targeting systems for cancer chemotherapy. Expert Opin Investig Drugs 1998; 7(11): 1849-64.
[http://dx.doi.org/10.1517/13543784.7.11.1849] [PMID: 15991934]
[64]
Nimesh S, Manchanda R, Kumar R, et al. Preparation, characterization and inin vitro drug release studies of novel polymeric nanoparticles. Int J Pharm 2006; 323(1-2): 146-52.
[http://dx.doi.org/10.1016/j.ijpharm.2006.05.065] [PMID: 16920286]
[65]
Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001; 70(1-2): 1-20.
[http://dx.doi.org/10.1016/S0168-3659(00)00339-4] [PMID: 11166403]
[66]
Jung T, Kamm W, Breitenbach A, Kaiserling E, Xiao JX, Kissel T. Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake? Eur J Pharm Biopharm 2000; 50(1): 147-60.
[http://dx.doi.org/10.1016/S0939-6411(00)00084-9] [PMID: 10840198]
[67]
Parveen S, Sahoo SK. Nanomedicine: Clinical applications of polyethylene glycol conjugated proteins and drugs. Clin Pharmacokinet 2006; 45(10): 965-88.
[http://dx.doi.org/10.2165/00003088-200645100-00002] [PMID: 16984211]
[68]
Orive G, Hernández RM, Rodríguez Gascón A, Domínguez-Gil A, Pedraz JL. Drug delivery in biotechnology: Present and future. Curr Opin Biotechnol 2003; 14(6): 659-64.
[http://dx.doi.org/10.1016/j.copbio.2003.10.007] [PMID: 14662398]
[69]
Arias JL. Key aspects in nanotechnology and drug delivery.Nanotechnology and drug delivery Volume 1: Nanoplatforms in drug delivery USA: CRC Press. 2014; pp. 1-27.
[http://dx.doi.org/10.1201/b17271]
[70]
Suri K, Wolfram J, Shen H, Ferrari M. Advances in nanotechnology-based drug delivery platforms and novel drug delivery systems. In: Novel approaches and strategies for biologics, vaccines and cancer therapies. USA: Academic Press 2015; pp. 41-58.
[http://dx.doi.org/10.1016/B978-0-12-416603-5.00003-1]
[71]
Ahmed S, Gull A, Aqil M, Danish Ansari M, Sultana Y. Poloxamer-407 thickened lipid colloidal system of agomelatine for brain targeting: Characterization, brain pharmacokinetic study and behavioral study on Wistar rats. Colloids Surf B Biointerfaces 2019; 181: 426-36.
[http://dx.doi.org/10.1016/j.colsurfb.2019.05.016] [PMID: 31176115]
[72]
Kawish SM, Ahmed S, Gull A, et al. Development of nabumetone loaded lipid nano-scaffold for the effective oral delivery; optimization, characterization, drug release and pharmacodynamic study. J Mol Liq 2017; 231: 514-22.
[http://dx.doi.org/10.1016/j.molliq.2017.01.107]
[73]
De Villiers MM, Aramwit P, Kwon GS, Eds. Nanotechnology in drug delivery. Germany: Springer Science & Business Media 2008.
[74]
Brambilla D, Le Droumaguet B, Nicolas J, et al. Nanotechnologies for Alzheimer’s disease: Diagnosis, therapy, and safety issues. Nanomedicine (Lond) 2011; 7(5): 521-40.
[http://dx.doi.org/10.1016/j.nano.2011.03.008] [PMID: 21477665]
[75]
Nazem A, Mansoori GA. Nanotechnology solutions for Alzheimer’s disease: Advances in research tools, diagnostic methods and therapeutic agents. J Alzheimers Dis 2008; 13(2): 199-223.
[http://dx.doi.org/10.3233/JAD-2008-13210] [PMID: 18376062]
[76]
Pardridge WM. Blood-brain barrier delivery. Drug Discov Today 2007; 12(1-2): 54-61.
[http://dx.doi.org/10.1016/j.drudis.2006.10.013] [PMID: 17198973]
[77]
Su Y, Sinko PJ. Drug delivery across the blood-brain barrier: Why is it difficult? how to measure and improve it? Expert Opin Drug Deliv 2006; 3(3): 419-35.
[http://dx.doi.org/10.1517/17425247.3.3.419] [PMID: 16640501]
[78]
Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 1994; 91(6): 2076-80.
[http://dx.doi.org/10.1073/pnas.91.6.2076] [PMID: 8134351]
[79]
Kroll RA, Pagel MA, Muldoon LL, Roman-Goldstein S, Neuwelt EA. Increasing volume of distribution to the brain with interstitial infusion: Dose, rather than convection, might be the most important factor. Neurosurgery 1996; 38(4): 746-52.
[http://dx.doi.org/10.1227/00006123-199604000-00024] [PMID: 8692395]
[80]
Abbott NJ. Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis 2013; 36(3): 437-49.
[http://dx.doi.org/10.1007/s10545-013-9608-0] [PMID: 23609350]
[81]
Mehnert W, Mäder K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 2012; 64: 83-101.
[http://dx.doi.org/10.1016/j.addr.2012.09.021] [PMID: 11311991]
[82]
Pang ZP, Yang N, Vierbuchen T, et al. Induction of human neuronal cells by defined transcription factors. Nature 2011; 476(7359): 220-3.
[http://dx.doi.org/10.1038/nature10202] [PMID: 21617644]
[83]
Wretlind A. Development of fat emulsions. JPEN J Parenter Enteral Nutr 1981; 5(3): 230-5.
[http://dx.doi.org/10.1177/0148607181005003230] [PMID: 6788972]
[84]
Kumar M, Misra A, Babbar AK, Mishra AK, Mishra P, Pathak K. Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm 2008; 358(1-2): 285-91.
[http://dx.doi.org/10.1016/j.ijpharm.2008.03.029] [PMID: 18455333]
[85]
Montenegro L, Lai F, Offerta A, et al. From nanoemulsions to nanostructured lipid carriers: A relevant development in dermal delivery of drugs and cosmetics. J Drug Deliv Sci Technol 2016; 32: 100-12.
[http://dx.doi.org/10.1016/j.jddst.2015.10.003]
[86]
Saupe A, Gordon KC, Rades T. Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy. Int J Pharm 2006; 314(1): 56-62.
[http://dx.doi.org/10.1016/j.ijpharm.2006.01.022] [PMID: 16574354]
[87]
Xia CF, Boado RJ, Zhang Y, Chu C, Pardridge WM. Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson’s disease with Trojan horse liposomes and a tyrosine hydroxylase promoter. J Gene Med 2008; 10(3): 306-15.
[http://dx.doi.org/10.1002/jgm.1152] [PMID: 18085726]
[88]
Xiang Y, Wu Q, Liang L, et al. Chlorotoxin-modified stealth liposomes encapsulating levodopa for the targeting delivery against Parkinson’s disease in the MPTP-induced mice model. J Drug Target 2012; 20(1): 67-75.
[http://dx.doi.org/10.3109/1061186X.2011.595490] [PMID: 22149216]
[89]
Kucherianu VG, Iurasov VV, Kryzhanovskiĭ GN, et al. The effect of liposomal form of L-Dopa on the development of parkinsonian syndrome in mice. Biull Eksp Biol Med 1997; 123(1): 29-33.
[PMID: 9213451]
[90]
Yurasov VV, Kucheryanu VG, Kudrin VS, et al. Effect of long-term parenteral administration of empty and L-Dopa-loaded liposomes on the turnover of dopamine and its metabolites in the striatum of mice with experimental Parkinson’s syndrome. Bull Exp Biol Med 1997; 123(2): 126-9.
[http://dx.doi.org/10.1007/BF02766431]
[91]
Jain NK, Rana AC, Jain SK. Brain drug delivery system bearing dopamine hydrochloride for effective management of parkinsonism. Drug Dev Ind Pharm 1998; 24(7): 671-5.
[http://dx.doi.org/10.3109/03639049809082370] [PMID: 9876513]
[92]
Sharma S, Rabbani SA, Narang JK, et al. Role of rutin nanoemulsion in ameliorating oxidative stress: Pharmacokinetic and pharmacodynamics studies. Chem Phys Lipids 2020; 228: 104890.
[http://dx.doi.org/10.1016/j.chemphyslip.2020.104890] [PMID: 32032570]
[93]
Migliore MM, Ortiz R, Dye S, Campbell RB, Amiji MM, Waszczak BL. Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of Parkinson’s disease. Neuroscience 2014; 274: 11-23.
[http://dx.doi.org/10.1016/j.neuroscience.2014.05.019] [PMID: 24845869]
[94]
Wang Y, Xu H, Fu Q, Ma R, Xiang J. Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats. J Neurol Sci 2011; 304(1-2): 29-34.
[http://dx.doi.org/10.1016/j.jns.2011.02.025] [PMID: 21376343]
[95]
Kang YS, Jung HJ, Oh JS, Song DY. Use of PEGylated immunoliposomes to deliver dopamine across the blood-brain barrier in a rat model of Parkinson’s disease. CNS Neurosci Ther 2016; 22(10): 817-23.
[http://dx.doi.org/10.1111/cns.12580] [PMID: 27350533]
[96]
Hsu SH, Wen CJ, Al-Suwayeh SA, Chang HW, Yen TC, Fang JY. Physicochemical characterization and in vivo bioluminescence imaging of nanostructured lipid carriers for targeting the brain: Apomorphine as a model drug. Nanotechnology 2010; 21(40): 405101.
[http://dx.doi.org/10.1088/0957-4484/21/40/405101] [PMID: 20823498]
[97]
Tsai MJ, Huang YB, Wu PC, et al. Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: Pharmacokinetic and behavioral evaluations. J Pharm Sci 2011; 100(2): 547-57.
[http://dx.doi.org/10.1002/jps.22285] [PMID: 20740670]
[98]
Meng F, Asghar S, Gao S, et al. A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer’s disease. Colloids Surf B Biointerfaces 2015; 134: 88-97.
[http://dx.doi.org/10.1016/j.colsurfb.2015.06.025] [PMID: 26162977]
[99]
Vedagiri A, Thangarajan S. Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25-35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer’s disease. Neuropeptides 2016; 58: 111-25.
[http://dx.doi.org/10.1016/j.npep.2016.03.002] [PMID: 27021394]
[100]
Yusuf M, Khan M, Khan RA, Ahmed B. Preparation, characterization, in vivo and biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer’s disease model. J Drug Target 2013; 21(3): 300-11.
[http://dx.doi.org/10.3109/1061186X.2012.747529] [PMID: 23231324]
[101]
Gunay MS, Ozer AY, Erdogan S, et al. Development of nanosized, pramipexole-encapsulated liposomes and niosomes for the treatment of Parkinson’s disease. J Nanosci Nanotechnol 2017; 17(8): 5155-67.
[http://dx.doi.org/10.1166/jnn.2017.13799]
[102]
Khan BA, Akhtar N, Khan HM, et al. Basics of pharmaceutical emulsions: A review. Afr J Pharm Pharmacol 2011; 5(25): 2715-25.
[103]
McClements DJ. Critical review of techniques and methodologies for characterization of emulsion stability. Crit Rev Food Sci Nutr 2007; 47(7): 611-49.
[http://dx.doi.org/10.1080/10408390701289292] [PMID: 17943495]
[104]
Hörmann K, Zimmer A. Drug delivery and drug targeting with parenteral lipid nanoemulsions - A review. J Control Release 2016; 223: 85-98.
[http://dx.doi.org/10.1016/j.jconrel.2015.12.016] [PMID: 26699427]
[105]
Davis SS, Washington C, West P, et al. Lipid emulsions as drug delivery systems. Ann N Y Acad Sci 1987; 507(1): 75-88.
[http://dx.doi.org/10.1111/j.1749-6632.1987.tb45793.x] [PMID: 3327420]
[106]
Gettings SD, Lordo RA, Feder PI, Hintze KL. A comparison of low volume, draize and in in vitro eye irritation test data. II. Oil/water emulsions. Food Chem Toxicol 1998; 36(1): 47-59.
[http://dx.doi.org/10.1016/S0278-6915(97)00110-5] [PMID: 9487363]
[107]
Singh M, Ravin LJ. Parenteral emulsions as drug carrier systems. J Parenter Sci Technol 1986; 40(1): 34-41.
[PMID: 3517276]
[108]
Venkateswarlu V, Reddy PR. Lipid microspheres as drug delivery systems. Indian J Pharm Sci 2001; 63(6): 450.
[109]
Zhang Q, Li F. Combating P-glycoprotein-mediated multidrug resistance using therapeutic nanoparticles. Curr Pharm Des 2013; 19(37): 6655-66.
[http://dx.doi.org/10.2174/1381612811319370009] [PMID: 23621532]
[110]
Shinde P, Vidyasagar N, Dhulap S, Dhulap A, Hirwani R. Natural products based p-glycoprotein activators for improved β-amyloid clearance in alzheimer’s disease: An in silico approach. Central Nervous Sys Agents Med Chem (Formerly Current Medicinal Chemistry-Central Nervous Sys-tem Agents) 2016; 16(1): 50.
[111]
Reis CP, Neufeld RJ, Ribeiro AJ, Veiga F, Nanoencapsulation I, Nanoencapsulation I. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine (Lond) 2006; 2(1): 8-21.
[http://dx.doi.org/10.1016/j.nano.2005.12.003] [PMID: 17292111]
[112]
Vauthier C, Bouchemal K. Methods for the preparation and manufacture of polymeric nanoparticles. Pharm Res 2009; 26(5): 1025-58.
[http://dx.doi.org/10.1007/s11095-008-9800-3] [PMID: 19107579]
[113]
Desgouilles S, Vauthier C, Bazile D, et al. The design of nanoparticles obtained by solvent evaporation: A comprehensive study. Langmuir 2003; 19(22): 9504-10.
[http://dx.doi.org/10.1021/la034999q]
[114]
Moinard-Chécot D, Chevalier Y, Briançon S, Beney L, Fessi H. Mechanism of nanocapsules formation by the emulsion-diffusion process. J Colloid Interface Sci 2008; 317(2): 458-68.
[http://dx.doi.org/10.1016/j.jcis.2007.09.081] [PMID: 17936772]
[115]
Alyautdin RN, Petrov VE, Langer K, Berthold A, Kharkevich DA, Kreuter J. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm Res 1997; 14(3): 325-8.
[http://dx.doi.org/10.1023/A:1012098005098] [PMID: 9098875]
[116]
Gelperina S, Maksimenko O, Khalansky A, et al. Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: Influence of the formulation parameters. Eur J Pharm Biopharm 2010; 74(2): 157-63.
[http://dx.doi.org/10.1016/j.ejpb.2009.09.003] [PMID: 19755158]
[117]
Ulbrich K, Hekmatara T, Herbert E, Kreuter J. Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur J Pharm Biopharm 2009; 71(2): 251-6.
[http://dx.doi.org/10.1016/j.ejpb.2008.08.021] [PMID: 18805484]
[118]
Tosi G, Costantino L, Rivasi F, et al. Targeting the central nervous system: In vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123. J Control Release 2007; 122(1): 1-9.
[http://dx.doi.org/10.1016/j.jconrel.2007.05.022] [PMID: 17651855]
[119]
Fornaguera C, Dols-Perez A, Calderó G, García-Celma MJ, Camarasa J, Solans C. PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier. J Control Release 2015; 211: 134-43.
[http://dx.doi.org/10.1016/j.jconrel.2015.06.002] [PMID: 26057857]
[120]
Singh Y, Meher JG, Raval K, et al. Nanoemulsion: Concepts, development and applications in drug delivery. J Control Release 2017; 252: 28-49.
[http://dx.doi.org/10.1016/j.jconrel.2017.03.008] [PMID: 28279798]
[121]
Salim N, Ahmad N, Musa SH, Hashim R, Tadros TF, Basri M. Nanoemulsion as a topical delivery system of antipsoriatic drugs. RSC Advances 2016; 6(8): 6234-50.
[http://dx.doi.org/10.1039/C5RA14946K]
[122]
Li W, Szoka FC Jr. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res 2007; 24(3): 438-49.
[http://dx.doi.org/10.1007/s11095-006-9180-5] [PMID: 17252188]
[123]
Vyas SP, Singh A, Sihorkar V. Ligand-receptor-mediated drug delivery: An emerging paradigm in cellular drug targeting. Crit Rev Ther Drug Carrier Sys 2001; 18(1): 1-76.
[124]
Newton HB. Advances in strategies to improve drug delivery to brain tumors. Expert Rev Neurother 2006; 6(10): 1495-509.
[http://dx.doi.org/10.1586/14737175.6.10.1495] [PMID: 17078789]
[125]
Bruxel F, Bochot A, Diel D, et al. Adsorption of antisense oligonucleotides targeting malarial topoisomerase II on cationic nanoemulsions optimized by a full factorial design. Curr Top Med Chem 2014; 14(9): 1161-71.
[http://dx.doi.org/10.2174/1568026614666140329230835] [PMID: 24678706]
[126]
Vinogradov SV, Bronich TK, Kabanov AV. Nanosized cationic hydrogels for drug delivery: Preparation, properties and interactions with cells. Adv Drug Deliv Rev 2002; 54(1): 135-47.
[http://dx.doi.org/10.1016/S0169-409X(01)00245-9] [PMID: 11755709]
[127]
Schwendener RA. Liposomes as vaccine delivery systems: A review of the recent advances. Ther Adv Vaccines 2014; 2(6): 159-82.
[http://dx.doi.org/10.1177/2051013614541440] [PMID: 25364509]
[128]
Moghassemi S, Hadjizadeh A. Nano-niosomes as nanoscale drug delivery systems: An illustrated review. J Control Release 2014; 185: 22-36.
[http://dx.doi.org/10.1016/j.jconrel.2014.04.015] [PMID: 24747765]
[129]
Zidan AS, Spinks C, Fortunak J, Habib M, Khan MA. Near-infrared investigations of novel anti-HIV tenofovir liposomes. AAPS J 2010; 12(2): 202-14.
[http://dx.doi.org/10.1208/s12248-010-9177-1] [PMID: 20195931]
[130]
Arumugam K, Subramanian GS, Mallayasamy SR, Averineni RK, Reddy MS, Udupa N. A study of rivastigmine liposomes for delivery into the brain through intranasal route. Acta Pharm 2008; 58(3): 287-97.
[http://dx.doi.org/10.2478/v10007-008-0014-3] [PMID: 19103565]
[131]
Mutlu NB, Değim Z, Yilmaz Ş, Eşsiz D, Nacar A. New perspective for the treatment of Alzheimer diseases: Liposomal rivastigmine formulations. Drug Dev Ind Pharm 2011; 37(7): 775-89.
[http://dx.doi.org/10.3109/03639045.2010.541262] [PMID: 21231901]
[132]
Zheng X, Shao X, Zhang C, et al. Intranasal H102 peptide-loaded liposomes for brain delivery to treat Alzheimer’s disease. Pharm Res 2015; 32(12): 3837-49.
[http://dx.doi.org/10.1007/s11095-015-1744-9] [PMID: 26113236]
[133]
Chen ZL, Huang M, Wang XR, et al. Transferrin-modified liposome promotes α-mangostin to penetrate the blood-brain barrier. Nanomedicine (Lond) 2016; 12(2): 421-30.
[http://dx.doi.org/10.1016/j.nano.2015.10.021] [PMID: 26711963]
[134]
Chen H, Tang L, Qin Y, et al. Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery. Eur J Pharm Sci 2010; 40(2): 94-102.
[http://dx.doi.org/10.1016/j.ejps.2010.03.007] [PMID: 20298779]
[135]
Kuo YC, Wang CT. Protection of SK-N-MC cells against β-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin. Biomaterials 2014; 35(22): 5954-64.
[http://dx.doi.org/10.1016/j.biomaterials.2014.03.082] [PMID: 24746790]
[136]
Markoutsa E, Papadia K, Giannou AD, et al. Mono and dually decorated nanoliposomes for brain targeting, in in vitro and in vivo studies. Pharm Res 2014; 31(5): 1275-89.
[http://dx.doi.org/10.1007/s11095-013-1249-3] [PMID: 24338512]
[137]
Kuo YC, Tsao CW. Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin. Int J Nanomedicine 2017; 12: 2857-69.
[http://dx.doi.org/10.2147/IJN.S132472] [PMID: 28435263]
[138]
Yang ZZ, Zhang YQ, Wang ZZ, Wu K, Lou JN, Qi XR. Enhanced brain distribution and pharmacodynamics of rivastigmine by liposomes following intranasal administration. Int J Pharm 2013; 452(1-2): 344-54.
[http://dx.doi.org/10.1016/j.ijpharm.2013.05.009] [PMID: 23680731]
[139]
Tanifum EA, Dasgupta I, Srivastava M, et al. Intravenous delivery of targeted liposomes to amyloid-β pathology in APP/PSEN1 transgenic mice. PLoS One 2012; 7(10): e48515.
[http://dx.doi.org/10.1371/journal.pone.0048515] [PMID: 23119043]
[140]
Rotman M, Welling MM, Bunschoten A, et al. Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer’s disease. J Control Release 2015; 203: 40-50.
[http://dx.doi.org/10.1016/j.jconrel.2015.02.012] [PMID: 25668771]
[141]
Gasco MR. Method for producing solid lipid microspheres having a narrow size distribution. US patent US 5,250,236, 1993.
[142]
Gasco MR. Lipid nanoparticles: Perspectives and challenges. Adv Drug Deliv Rev 2007; 59(6): 377-8.
[http://dx.doi.org/10.1016/j.addr.2007.05.004] [PMID: 17582649]
[143]
Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm 2000; 50(1): 161-77.
[http://dx.doi.org/10.1016/S0939-6411(00)00087-4] [PMID: 10840199]
[144]
Raman S, Mahmood S, Hilles AR, Javed MN, Azmana M, Al-Japairai KAS. Polymeric nanoparticles for brain drug delivery - a review. Curr Drug Metab 2020; 21(9): 649-60.
[http://dx.doi.org/10.2174/1389200221666200508074348] [PMID: 32384025]
[145]
Dolatabadi JE, Omidi Y. Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems. Trends Analyt Chem 2016; 77: 100-8.
[http://dx.doi.org/10.1016/j.trac.2015.12.016]
[146]
Pottoo FH, Javed N, Rahman J, Abu-Izneid T, Khan FA. Targeted delivery of miRNA based therapeuticals in the clinical management of glioblastoma multiforme. Semin Cancer Biol 2021; 69: 391-8.
[147]
Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: Structure, preparation and application. Adv Pharm Bull 2015; 5(3): 305-13.
[http://dx.doi.org/10.15171/apb.2015.043] [PMID: 26504751]
[148]
Feng L, Mumper RJ. A critical review of lipid-based nanoparticles for taxane delivery. Cancer Lett 2013; 334(2): 157-75.
[http://dx.doi.org/10.1016/j.canlet.2012.07.006] [PMID: 22796606]
[149]
Müller RH, Radtke M, Wissing SA. Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 2002; 242(1-2): 121-8.
[http://dx.doi.org/10.1016/S0378-5173(02)00180-1] [PMID: 12176234]
[150]
Eskandari S, Varshosaz J, Minaiyan M, Tabbakhian M. Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: In vivo pharmacodynamic studies using rat electroshock model. Int J Nanomedicine 2011; 6: 363-71.
[PMID: 21499426]
[151]
Tsai MJ, Wu PC, Huang YB, et al. Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting. Int J Pharm 2012; 423(2): 461-70.
[http://dx.doi.org/10.1016/j.ijpharm.2011.12.009] [PMID: 22193056]
[152]
Alam MI, Baboota S, Ahuja A, Ali M, Ali J, Sahni JK. Intranasal administration of nanostructured lipid carriers containing CNS acting drug: Pharmacodynamic studies and estimation in blood and brain. J Psychiatr Res 2012; 46(9): 1133-8.
[http://dx.doi.org/10.1016/j.jpsychires.2012.05.014] [PMID: 22749490]
[153]
Alam MI, Baboota S, Ahuja A, Ali M, Ali J, Sahni JK. Nanostructured lipid carrier containing CNS acting drug: Formulation, optimization and evaluation. Curr Nanosci 2011; 7(6): 1014-27.
[http://dx.doi.org/10.2174/1573413711107061014]
[154]
Li F, Wang Y, Liu Z, Lin X, He H, Tang X. Formulation and characterization of bufadienolides-loaded nanostructured lipid carriers. Drug Dev Ind Pharm 2010; 36(5): 508-17.
[http://dx.doi.org/10.3109/03639040903264397] [PMID: 19821716]
[155]
Alam T, Pandit J, Vohora D, Aqil M, Ali A, Sultana Y. Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: In in vitro characterization and in vivo efficacy in epilepsy. Expert Opin Drug Deliv 2015; 12(2): 181-94.
[http://dx.doi.org/10.1517/17425247.2014.945416] [PMID: 25164097]
[156]
Tapeinos C, Battaglini M, Ciofani G. Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. J Control Release 2017; 264: 306-32.
[http://dx.doi.org/10.1016/j.jconrel.2017.08.033] [PMID: 28844756]
[157]
Barenholz Y, Ovadia H, Pablo KP. Liposomal formulations comprising an amphipathc weak base like tempamine for treatment of neurodegenerative conditions. US Patent 2011/0027351A1 2010.
[158]
Baker JR, Cheng XM, Abraham FL, Spek VD, Huang BM. Dendrimer conjugates. Psychotic disorders. US Patent 2010/0160299 A1, 2010.
[159]
Frautschy SA, Cole GM. Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders. PCT patent WO 2007/103435 A2, 2007.
[160]
Ivri Y. Intracochlear drug delivery to the central nervous system. PCT patent WO 2011/019954 A2, 2011.
[161]
Anton N, Saulnier P. Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules. PCT patent WO2009037310 A2, 2009.
[162]
Saulnier P, Benoit JP. Nanocapsules with liquid lipidic core loaded with water-soluble or water-dispersible ingredient(s). PCT patent WO2009001019A2, 2008.
[163]
Saulnier P, Benoit JP, Anton N. Method for preparing lipid nanoparticles. PCT patent WO 2009004214 A2, 2009.
[164]
Heurtault B, Patrick Saulnier P, Benoit JP. Lipid nanocapsules, preparation process and use as medicine. US Patent 20090238865 A1, 2009.
[165]
Panyam J, Chavanpatil MD. Lipid-derived nanoparticles for brain- targeted drug delivery. PCT patent WO 2008/024753 A2, 2007.
[166]
Roger E, Lagarce F. Lipid nanocapsules, method for preparing same, and use thereof as a drug. PCT patent WO 2011036234 A1, 2010.

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