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摘要
背景:氧化应激和自由基对人体健康有害。活性氧是氧化应激的主要来源,也是癌症发展的主要原因之一。癌症是世界范围内导致死亡的主要原因之一。由于合成化学治疗剂的生物利用度低,长期使用它们会导致全身毒副作用。为了克服这个问题,建议使用抗氧化剂,因为它们能够抵消氧化应激并减轻其对人类健康的影响。它们抑制与癌症发生和发展有关的各种途径。各种纳米制剂已被用于提供这些抗氧化剂(姜黄素、芒果苷、槲皮素),用于治疗各种癌症以克服氧化应激。 目的:这篇评论文章的主要重点是说明使用天然生物活性物质的纳米载体来克服氧化应激和与之相关的癌症的各种研究。它还描述了与由于活性氧化物质引起的癌症的诱导、起始和进展相关的途径。 方法:从 PubMed、Science Direct 和 Google Scholar 等各种搜索引擎中,使用氧化应激、抗氧化剂、癌症、ROS等。 结论:天然生物活性物质在克服氧化应激治疗各种癌症方面显示出巨大潜力。然而,需要进行广泛的研究,以便在不久的将来,这些抗氧化剂及其纳米载体可用于造福人类,治疗各种癌症。
关键词: 氧化应激、活性氧、癌症、纳米制剂、天然生物活性物质、纳米载体。
Current Medicinal Chemistry
Title:Role of Natural Bioactives and their Nanocarriers for Overcoming Oxidative Stress Induced Cancer
Volume: 28 Issue: 36
关键词: 氧化应激、活性氧、癌症、纳米制剂、天然生物活性物质、纳米载体。
摘要:
Background: Oxidative stress and free radicals are harmful to human health. Reactive oxygen species are the major source of oxidative stress and are one of the major causes of cancer development. Cancer is one of the leading causes of death worldwide. Prolonged use of synthetic chemotherapeutic due to their low bioavailability leads to systemic toxic side effects. To surmount this problem, the use of antioxidants is recommended as they have the ability to counteract oxidative stress and mitigate its effects on human health. They inhibit various pathways that are involved with the initiation and progression of cancer. Various nanoformulations have been used to deliver these antioxidants (curcumin, mangiferin, quercetin) in the treatment of various cancer for overcoming oxidative stress.
Objective: The main focus of this review article is to illustrate various studies performed using nanocarriers of natural bioactives to overcome oxidative stress and cancer associated with it. It also describes pathways associated with the induction, initiation and progression of cancer due to reactive oxidative species.
Methods: Research articles that focused on the use of natural bioactives and their nanoformulations for the treatment of various cancers induced due to oxidative stress, were collected from various search engines like PubMed, Science Direct and Google Scholar, using keywords like oxidative stress, antioxidants, cancers, ROS, etc.
Conclusion: Natural bioactives have shown great potential in overcoming oxidative stress for the treatment of various cancers. However, extensive research is required so that these antioxidants and their nanocarriers can be used for the welfare of mankind, in the treatment of various cancers, in the near future.
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Cite this article as:
Role of Natural Bioactives and their Nanocarriers for Overcoming Oxidative Stress Induced Cancer, Current Medicinal Chemistry 2021; 28 (36) . https://dx.doi.org/10.2174/0929867328666210628141550
DOI https://dx.doi.org/10.2174/0929867328666210628141550 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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