Title:Gut Microbiota and Inflammatory Disorders
Volume: 23
Issue: 2
关键词:
微生物群、食物过敏、关节炎、IBD、糖尿病、SLE
摘要: The gut has been colonized with bacteria, fungi, viruses, archaea, eukarya. The human
and bacterial cells are found in a 1:1 ratio, while the variance in the diversity of gut microbiota
may result in dysbiosis. Gut dysbiosis may result in various pathological manifestations. Beneficial
gut microbiota may synthesize short-chain fatty acids like acetate, butyrate, propionate. Gram-negative
organisms are the primary source of LPS, a potent pro-inflammatory mediator. Both gut microbiota
and microbial products may be involved in immunomodulation as well as inflammation. Prebiotics
and probiotics are being explored as therapeutic agents against various inflammatory and autoimmune
disorders. Here, we discuss the molecular mechanisms involved in gut bacteria mediated
modulation of various inflammatory and autoimmune disorders.