Title:Parkinson’s Disease: A Current Perspectives on Parkinson’s Disease and
Key Bioactive Natural Compounds as Future Potential Drug Candidates
Volume: 23
Issue: 1
关键词:
帕金森病、多巴胺、天然产物、新兴疗法、神经退行性疾病、α-突触核蛋白。
摘要: Abstract: Parkinson’s disease (PD) is one of the most common types of neurological disorder prevailing
worldwide and is rapidly increasing in the elderly population across the globe. The cause of
PD is still unknown, but a number of genetic as well as environmental factors contributing to the
pathogenesis of Parkinson’s disease have been identified. The hallmark of PD includes dopamine
deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia
nigra in the midbrain. Studying the mutation of associated genes is particularly informative in
understanding the fundamental molecular and pathogenic changes in PD. Intracellular accumulation
of misfolded or degraded protein due to mutated genes leading to the manifestation of mitochondrial
dysfunction, oxidative stress followed by multifaceted patho-physiologic symptoms. Other studies
include the appearance of both motor and non-motor responses like resting tremor, muscle stiffness,
slow movement and anxiety, anaemia, constipation, rapid eye movement sleep behaviour disorder.
Many bioactive natural compounds have shown positive pharmacological results in treating a number
of extensive disease models of PD. Despite the availability of end number of potent medicinal plants
around the world, limited research has been done associated with various neurological disorders, including
PD. The currently available dopamine-based drug treatments have several side-effects, further,
not effective enough to combat PD completely. Therefore, various plant-based compounds with
medicinal benefits have grabbed lots of attention of researchers to deal with various life-threatening
neurodegenerative disorders like PD. On the basis of literature available till date, here, we have discussed
and addressed the molecular basis, current scenario, and the best possible treatment of PD for
the future with minimal or no side-effects using various key bioactive compounds from natural
origin/medicinal plants.