摘要
干扰素诱导的四三肽重复序列蛋白(IFIT)家族是抗病毒免疫应答的重要组成部分。目前已知人类有4个IFIT家族成员,分别是IFIT1、IFIT2、IFIT3和IFIT5。最新的研究引起了人们对IFITs在癌症中的重要作用的关注。本文综述了目前关于不同IFIT蛋白在不同类型恶性肿瘤中生物学作用的研究,并强调了这些分子作为癌症生物标志物和预后因素的潜在用途。
关键词: 癌症,干扰素诱导蛋白,四三肽重复序列,IFIT,生物标志物,预后因子。
Current Medicinal Chemistry
Title:Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer
Volume: 28 Issue: 25
关键词: 癌症,干扰素诱导蛋白,四三肽重复序列,IFIT,生物标志物,预后因子。
摘要: The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.
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Cite this article as:
Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666210617105209
DOI https://dx.doi.org/10.2174/0929867328666210617105209 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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