Title:Combination Therapy as a Strategy to Control Infections Caused by
Multi-resistant Bacteria: Current Review
Volume: 23
Issue: 3
关键词:
抗菌素耐药性、传染病、药物组合、天然产物、联合疗法、协同作用
摘要: Antimicrobial Resistance (AMR) is one of the main challenges of today's medicine because
it has become a global problem that affects the treatment of multiple infections and impacts
public health. This resistance is caused as the bacteria generate selective pressure-promoting
mechanisms to evade the action of conventional drugs, which are also associated with adverse
effects. Infections caused by these multi-resistant bacteria potentially reduce the possibility of effective
therapy; this situation increases morbidity and mortality and treatment costs. Therefore, to
establish combined therapy as a strategy for the control of infections caused by multi-resistant bacteria,
a bibliographic search was carried out between 2015 and 2020 in databases such as PubMed,
Scopus and Science Direct. The exhaustive review of the articles allowed a critical analysis of the
information. Mechanisms were identified for obtaining drugs with antimicrobial potential, their biological
activity and the possible effect of their combination against multidrug-resistant bacteria as
an alternative for infectious disease control and as a response to reduce the use of antibiotics. Combined
therapy is presented as an innovative therapeutic alternative, which uses non-antibiotic substances
that can be obtained by three routes: the repositioning of drugs, synthetic substances and natural
products. In this way, important elements are provided to guide researches that seek to reduce
antimicrobial resistance.