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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)

Author(s): Xiang Zheng and Ravindra K. Pandey

Volume 8, Issue 3, 2008

Page: [241 - 268] Pages: 28

DOI: 10.2174/187152008783961897

Price: $65

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Abstract

In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published.1 Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing targetspecific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.

Keywords: Photodynamic therapy, Photofrin®, Porphyrin, Carbohydrate-Porphyrin Conjugates


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