Title:Targeted Drug Delivery: Trends and Perspectives
Volume: 18
Issue: 10
Author(s): Sumel Ashique, Navjot Kaur Sandhu, Viney Chawla and Pooja A. Chawla*
Affiliation:
- Department of Pharmaceutical Analysis, ISF College of Pharmacy, Moga-142001, Punjab,India
Keywords:
Targeted drug delivery, colon targeting, folate receptor targeting, brain targeting approaches, polymers, active pharmaceutical ingredients.
Abstract:
Background: Having various limitations in conventional drug delivery system, it is important
to focus on the target-specific drug delivery system where we can deliver the drug without
any degradation. Among various challenges that are thrown to a formulation scientist, delivering
the drug to its right site, in its right dose, is also an important aim. A focused drug transport aims to
extend, localize, target and have a safe drug interaction with the diseased tissue.
Objective: The aim of targeted drug delivery is to make the required amount of the drug available
at its desired site of action. Drug targeting can be accomplished in a number of ways that include
enzyme mediation, pH-dependent release, use of special vehicles, receptor targeting, among other
mechanisms. Intelligently designed targeted drug delivery systems also offer the advantages of a
low dose of the drug along with reduced side effects which ultimately improves patient compliance.
Incidences of dose dumping and dosage form failure are negligible. A focused drug transport
aims to have a safe drug interaction with the diseased tissue.
Conclusion: This review focuses on the available targeting techniques from experiment to perfection
for delivery to the colon, brain, and other sites of interest. Overall, the article should make an
excellent read for the researchers in this area. Newer drug targets may be identified and exploited
for successful drug targeting.
