Title:Recent Achievements in the Synthesis of Oxazoles
Volume: 25
Issue: 15
Author(s): Dau Xuan Duc*Nguyen Thi Chung
Affiliation:
- Department of Chemistry, Vinh University, Vinh City,Vietnam
Keywords:
Toluenesulfonylmethyl isocyanide, 2-acylamino-ketones, propargylamides, 5-exo-dig cyclization, multisubstituted oxazoles, antiinflammatory.
Abstract: Oxazole-containing compounds have diverse biological activities, such as antimicrobial,
anticancer,
antitubercular, antiinflammatory,
antidiabetic, antiobesity, antimalarial,
and antiviral activities, and some of them have been used as drugs for treating diseases.
They also play important roles in the synthesis of bioactive natural products, pharmaceuticals
and synthetic transformations as well as in materials, catalyst and agriculture fields. Thus, the
development of more efficient and facile synthetic approaches to access oxazole compounds
has attracted the intensive interest of chemists, and diverse methods for their synthesis have
been investigated. Various established methods have been improved and modified, while numerous
novel methods have been discovered. This article will summarize considerable studies
on the construction of the oxazole skeleton which date back to 2014.