Title:Advancements in the Functionalization of Aryl C-sp2 and Alkyl C-sp3 of Toluene Derivatives via C-H Activation
Volume: 25
Issue: 15
Author(s): Kevin George and Sathananthan Kannadasan *
Affiliation:
- Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu,India
Keywords:
Toluene, C-H activation, C-C coupling, C-heteroatom bond formation, cross dehydrogenative coupling, directing groups.
Abstract: Toluene and its derivatives have been well established as versatile scaffolds in organic
synthesis over the last few decades. This review provides a brief and concise overview of
the current status and latest methodologies in the synthetic utility of toluene and its derivatives
by exploiting both the alkyl-sp3 and aryl-sp2 carbons via C-H activation. The review also explores
the effect of various substituents on the toluene derivatives in facilitating different reactions.