Title:Targeting Notch Pathway in Cancer Diagnostics and Therapeutics: An Emerging Approach
Volume: 17
Issue: 3
Author(s): Chakresh Kumar Jain*, Shreya Bhargava, Isha Jain and Srishti Varshney
Affiliation:
- Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector -62 Noida Uttar Pradesh,
India, 201307
Keywords:
Notch pathway, dysregulation, cancer stem cells, NICD, γ secretase, mRNA.
Abstract: The Notch signaling pathway is an evolutionarily conserved pathway usually present in
multicellular organisms, which plays a pivotal role in cell fate determination and proliferation. Due
to this property, it is known to be highly oncogenic, especially in the dysregulated version of the
Notch pathway, where apoptosis is inhibited and abnormal cell growth is supported. Notch receptors
and ligand proteins play an essential role in cancers, such as myeloid leukemia, T-cell lymphoblastic
leukemia, and organ-specific, i.e., breast, colon, pancreas, and skin cancers. Any type of
cancer generates due to genetic defects, including epigenetic alterations and mutations. The researchers
can use these alterations to find a promising diagnostic as well as therapeutic tool for cancer.
The successful inhibition of the Notch pathway with the help of specific biomarkers or suppression
of gene expression represents a new remedy in cancer research. This article focuses on the
various remedies hidden within the Notch pathway's mechanism, primarily based on different patents
published in recent years for assisting cancer diagnosis and succeeding treatment.
