噻吩并 [3,2-d] 嘧啶衍生物的治疗潜力、合成、专利评估和 SAR 研究：最新动态

Title:Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates

Volume: 22 Issue: 17

关键词: 生物活性、药物分子、杂环化合物、专利、构效关系 (SAR)、噻吩并[3

摘要: Thieno[3,2-d]pyrimidine ring framework comprises a significant class of heterocyclics that serve as a promising platform showing different pharmacological activities. The interest in thieno[3,2-d]pyrimidine cores for pharmaceutical products makes this scaffold an exceptionally helpful building block for organic chemistry. This review presents current research on thieno[3,2- d]pyrimidines and elucidates their biological importance in anti-cancer, anti-infectious, anticonvulsant, anti-diabetic, CNS, and osteoporosis drug discoveries. Patents on the thieno[3,2- d]pyrimidines are also elaborated as a piece of useful information. Here, we additionally focus on the synthesis of this vital ring and the discovery of new thieno[3,2-d]pyrimidines.

Cite this article as:

Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates, Current Drug Targets 2021; 22 (17) . https://dx.doi.org/10.2174/1389450122666210526094047