Title:New Horizons in the Treatment of Neurological Disorders with Tailorable Gold
Nanoparticles
Volume: 22
Issue: 12
Author(s): Farheen , Md. Asad Khan*, Ghulam Md. Ashraf, Anwar L. Bilgrami and M. Moshahid A. Rizvi
Affiliation:
- Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
Keywords:
Neurodegeneration, blood brain barrier, nanotechnology, gold nanoparticles, neurological disorders, therapeutic drug approaches.
Abstract: Neurological disorders, such as epilepsy, dementia, Parkinson’s disease and Alzheimer’s disease,
occur due to disorganization of the neurons in the nervous system. Disturbances in the nervous system cause
problems with the memory, senses and moods. In order to treat such disorders, scientists have been working
extensively, utilizing different approaches. Nanoneurotechnology has emerged as a promising tool to manage
these complicated disorders, where nanoparticles with their tunable properties such as size, shape, increased
solubility, biodegradability, surface area and sharp penetration through the biological barriers, target the central
nervous system. This technology targets damaged neurons without affecting healthy neurons and the
Blood-Brain Barrier (BBB). In this review, we discuss neurological disorders and challenges in their diagnosis
and treatment by emphasizing on the role of tailorable gold nanoparticles in therapeutic drug approaches.
