Title:Heterogeneous Metal Catalysis for the Environmentally Benign Synthesis of Medicinally Important Scaffolds, Intermediates, and Building Blocks
Volume: 25
Issue: 20
Author(s): Maysa Ilamanova, Maxim Mastyugin, Christian Schäfer, Anne Kokel and Béla Török*
Affiliation:
- Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, MA 02125,United States
Keywords:
Heterogeneous catalysis, solid metal catalysts, hydrogenation, hydrogenolysis, oxidation, metathesis, cross-coupling reactions,
hydroformylation.
Abstract: This account provides a broad overview of the application of solid metal catalysts
in synthetic chemistry with a focus on the synthesis of medicinally important scaffolds or
building blocks. Heterogeneous catalysis is a fundamental contributor to green or sustainable
synthesis. Despite this, many synthetic chemists overwhelmingly focus on homogeneous
methods, and due to their unfamiliarity with solid catalysts, many would not consider using
them. The primary purpose of this work is to bring solid catalysts and their application
possibilities to the attention of synthetic chemists in a format that focuses on reactions, thus
building a bridge between the two sides for the benefit of sustainable applications and,
eventually, the whole society. The two major parts of this account describe the common types
of solid metal catalysts and the applications of these catalysts in sustainable synthesis. The
first part gives an overview of the major types of solid metal catalysts, including common hydrogenation catalysts to
metal nanoparticles. The second and more extensive part illustrates the use of these catalysts in a thematic order
based on reaction types, including hydrogenation, hydrogenolysis, oxidation, metathesis, cross-coupling reactions,
and hydroformylation.
