Title:A Link Between Chemical Structure and Biological Activity in Triterpenoids
Volume: 17
Issue: 2
Author(s): Li Zang, Hao Xu, Chao Huang, Cunqin Wang*, Rongbin Wang*, Ying Chen, Lei Wang and Hongting Wang*
Affiliation:
- College of Pharmacy, Wannan Medical College, Wuhu, Anhui 241002, and Anhui College of Traditional Chinese
Medicine, Anhui, China
- Anhui College of
Traditional Chinese Medicine, Anhui, China
- College of Pharmacy, Wannan Medical College, Wuhu, Anhui 241002, and Anhui College of Traditional Chinese
Medicine, Anhui, China
Keywords:
Triterpenoids, classification, chemical structure, programmed cell death, autoghagy, apoptosis.
Abstract:
Background: Plants that are rich in triterpenoid compounds possess various biological
activities and are reported in many scientific works. Triterpenoids, because of their broad sources,
wide variety, high medicinal value, and anti-tumor properties, have drawn great attention from scientists.
However, the lack of approach to understand the link between their chemical structures and
biological activities has limited the fundamental comprehension of these compounds in cancer therapy.
Objective: The aim of the study is to summarize the list of plants with triterpenoids and their derivatives
that are a source of potential novel therapeutic anti-cancer agents by interpreting the network
of anti-cancer activity and the structures of triterpenoids and their derivatives.
Methods: This work focuses on analyzing relevant patents and references that detail the structure
of triterpenoids and their derivatives for the treatment of tumors.
Results: Pentacyclic triterpenoid plays a more important role in improving the autophagic signaling
pathways of cancer cells compared to tetracyclic triterpenoid.
Conclusion: The heterogenous skeleton structure of triterpenoids impairs programmed cell death
signaling pathways in various cancers.
