Title:Recent Advances in Synthesis and Reactions of β-Amino-α ,β -Enones (Enaminones)
Volume: 18
Issue: 7
Author(s): Thoraya Farghaly*, Alaa M. Abo Alnaja and Mohamed R. Shaaban*
Affiliation:
- Department of Chemistry, Faculty of Science, Cairo University, Giza 12613,Egypt
- Department of Chemistry, Faculty of Science, Cairo University, Giza 12613,Egypt
Keywords:
Enaminones, nitrogen nucleophiles, heterocycles, synthesis, β-enamino, β-amino-α, β-enones.
Abstract: β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for
the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic
precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the
different synthetic routes to obtain β−amino−α,β-enones or β-enamino carbonyl compounds, their reactions,
and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β-
amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and
electrophilicity of enones at the same time. β-amino-α,β-enones have been known as acceptors in both 1,2- and
1,4- additions that make them good intermediate compounds for annulation to different heterocycles.