Title:A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents
Volume: 21
Issue: 12
Author(s): Tanima Bhattacharya, Samka P. Maishu, Rokeya Akter, Md. H. Rahman*, Muhammad F. Akhtar, Ammara Saleem, May Bin-Jumah, Mohamed Kamel, Mervat A. Abdel-Latif and Mohamed M. Abdel-Daim*
Affiliation:
- Department of Pharmacy, Southeast University, Banani, Dhaka-1213,Bangladesh
- Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451,Saudi Arabia
Keywords:
Drug delivery system, Nanomedicine, Carcinoma, Nanoparticles, Mushroom, PNPs.
Abstract: Cancer notably carcinoma represents a prominent health challenge worldwide. A variety
of chemotherapeutic agents are being used to deal with a variety of carcinomas. However, these delivering
agents not only enter the targeted site but also affect normal tissues yielding poor therapeutic
outcomes. Chemotherapeutic-associated problems are being attributed to drug non-specificity resulting
from poor drug delivery systems. These problems are now being solved using
nanomedicine, which entails using nanoparticles as drug delivery systems or nanocarriers. This
nanoparticle-based drug delivery system enhances clinical outcomes by enabling targeted delivery,
improving drug internalization, enhanced permeability, easy biodistribution, prolonged circulation
and enhanced permeability rate, thereby improving the therapeutic effectiveness of several anticancer
agents. Natural Protein-based Nanoparticles (PNPs) such as ferritin, lipoprotein, and lectins
from natural sources have gained extensive importance at a scientific community level as nanovehicle
for effective drug delivery and photo acoustic labeling replacing several synthetic nanocarriers
that have shown limited therapeutic outcomes. The bioavailability of PNP, the chance of genetic engineering
techniques to modify their biological properties made them one of the important raw material
sources for drug delivery research. This current review highlighted different chemotherapeutic
agents used in the treatment of some carcinomas. It also focused on the wide variety of natural
protein sources derived nanoparticles (NPs) as anticancer delivery of agents for cancer therapy.
