摘要
纳米医学是一个新兴领域,它利用纳米技术概念进行开创性的治疗和诊断。与临床实验室诊断中的传统系统相比,用于肿瘤标志物的比色传感器显示出有趣的优势。基于比色免疫测定的方法显示出即将到来的结果,因为目标癌症标记物以高灵敏度确定,但不使用先进/昂贵的技术,通过轻松的光学颜色变化。此外,比色生物传感器具有以高灵敏度快速检测生物体液中蛋白质的潜力,预计它们将在肿瘤诊断中发挥越来越重要的作用。我们回顾了(涵盖 2015-2020 年期间)基于比色传感策略使用纳米结构材料(高效酶模拟物、人工酶或纳米酶)检测生物体液中不同肿瘤抗原的各种研究。具体而言,我们重点介绍了比色免疫传感器构建方面的最新进展和努力。比色免疫传感器大致可分为两大类:基于过渡金属纳米酶的传感和基于贵金属纳米酶的传感。
关键词: 肿瘤标志物、酶模拟物、人工酶、纳米酶、纳米颗粒、比色法、纳米医学、临床分析。
Current Medicinal Chemistry
Title:A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials
Volume: 28 Issue: 30
关键词: 肿瘤标志物、酶模拟物、人工酶、纳米酶、纳米颗粒、比色法、纳米医学、临床分析。
摘要: Nanomedicine is an arising field that exploits nanotechnology concepts for pioneered therapy and diagnostics. Colorimetric sensors for tumor markers have displayed interesting benefits compared to conventional systems in clinical laboratory diagnosis. Colorimetric immunoassay-based approaches show up-and-coming results since the goal cancer marker is determined with high sensitivity but without the utilization of advanced/- expensive techniques through an effortless optical color change. Also, colorimetric biosensor has the potential to detect proteins in biological fluids swiftly with high sensitivity, and they are anticipated to play a progressively serious role in tumor diagnosis. We reviewed (covering the period 2015-2020) various studies based on colorimetric sensing strategy using nanostructured materials (highly efficient enzyme mimics, artificial enzymes or nanozymes) to detect different tumor antigens in biological fluids. Specifically, we highlighted the recent progress and efforts in the construction of colorimetric immunosensors. Colorimetric immunosensors can be roughly divided into two main categories: transition metal nanozyme-based sensing and noble metal nanozyme-based sensing.
Export Options
About this article
Cite this article as:
A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials, Current Medicinal Chemistry 2021; 28 (30) . https://dx.doi.org/10.2174/0929867328666210412122604
DOI https://dx.doi.org/10.2174/0929867328666210412122604 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases
Current Medicinal Chemistry Chaperone-like Activity of alpha-Crystallin and Other Small Heat Shock Proteins
Current Protein & Peptide Science Ultrasound and Microbubble Guided Drug Delivery: Mechanistic Understanding and Clinical Implications
Current Pharmaceutical Biotechnology Exploring Natural Products as a Source for Antidiabetic Lead Compounds and Possible Lead Optimization
Current Topics in Medicinal Chemistry Pharmacogenomics of Open-Angle Glaucoma
Current Pharmacogenomics and Personalized Medicine Pidotimod and Immunological Activation in Individuals Infected with HIV
Current HIV Research Models for the Study of Angiogenesis
Current Pharmaceutical Design Anti-VEGF Treatment and Response in Age-related Macular Degeneration: Disease’s Susceptibility, Pharmacogenetics and Pharmacokinetics
Current Medicinal Chemistry Advanced Biomedical Techniques for Gene Delivery
Recent Patents on Biomedical Engineering (Discontinued) Small Molecule Antagonists of Integrin Receptors
Current Medicinal Chemistry Applications of the Rare Earth Elements in Cancer Imaging and Therapy
Current Nanoscience Withdrawal Notice: Emerging Biomarkers and Contributing Factors of Prostate Cancer
Current Cancer Therapy Reviews Pyrimidine Salvage Pathway in Mycobacterium tuberculosis
Current Medicinal Chemistry Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids
Mini-Reviews in Medicinal Chemistry Loss of Eyebrows and Eyelashes During Concomitant Treatment with Sitagliptin and Metformin
Current Drug Safety Antibodies As Promising Novel Neuroprotective Agents in the Central Nervous System Injuries
Central Nervous System Agents in Medicinal Chemistry FDG-PET Scan in Sarcoidosis: Clinical and Imaging Indications
Current Medical Imaging Using Current Data to Define New Approach in Age Related Macular Degeneration: Need to Accelerate Translational Research
Current Genomics Molecular and Biochemical Changes of the Cardiovascular System due to Smoking Exposure
Current Pharmaceutical Design Adeno-Associated Viral Vector Mediated Expression of Broadly- Neutralizing Antibodies Against HIV-Hitting a Fast-Moving Target
Current HIV Research