Title:Mechanism of Natural Drugs on Nonalcoholic Fatty Liver Disease
Volume: 21
Issue: 19
Author(s): Jiao Xie, Ling Li and Lei Zhao*
Affiliation:
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, 430022, P.R. China
Keywords:
Non-alcohol fatty liver disease, natural drugs, mechanism, chronic liver disease, type 2 diabetes, hyperlipidemia .
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the
world. Its pathogenesis is closely related to insulin resistance, obesity, type 2 diabetes, and hyperlipidemia.
Due to the complex pathogenesis, there are no specific medications for treating NAFLD. The
most effective way to treat NAFLD is to lose weight through diet intervention and exercise, but a large
number of in vitro and in vivo experiments have confirmed that a variety of natural drugs can interfere
with NAFLD through many mechanisms, and the curative effect is remarkable. This paper reviews the
action mechanism of crude extracts of medicinal plants (Polygonum multiflorum, Artemisia annua
leaves, and Artemisia annua leaves) and natural products such as berberine (BBR), curcumin, betulinic
acid (BA), ginsenoside Rg1 (G-rg1), and silybin on NAFLD, which aims to provide useful information
for further research and development of new drugs to improve the cure rate of non-alcoholic fatty liver.