Title:Modifiable Risk Factors Associated with Alzheimer’s Disease with Special Reference to Sleep Disturbance
Volume: 20
Issue: 7
Author(s): Pallavi Singh Chauhan, Meerambika Mishra, Bhupendra Koul, Mayank Sharma and Dhananjay Yadav*
Affiliation:
- Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541,South Korea
Keywords:
Alzheimer's disease, dementia, impaired sleep, insomnia, cognitive impairment, sleep disturbance.
Abstract: Sleep disorders have been shown to increase the risk of dementia. This particular aspect
may affect the cognition of the patient, leading to behavioral disorders and depression. In early
symptomatic Alzheimer’s Disease (AD), Default Mode Network (DMN) disruption occurs and progresses
along with the course of the disease. This review mainly focuses on the leading causes of
AD along with management of conditions like insomnia, obstructive sleep apnea, night-time sleep
duration, Circadian Rhythm Disorder (CRD), neuroendocrine alternation, and impaired sleep to prevent
the use of drugs that can cause complications, especially falls or additional cognitive deficits.
Moreover, this study highlights the identification of molecular mechanisms like the effect of impaired
sleep on amyloid β (Aβ) and tau dynamics, impaired proteostasis, along with appropriate
measures to treat few contributing factors that lead to insomnia in AD or Mild Cognitive Impairment
(MCI).
