摘要
背景:癌细胞的特点是代谢异质性。尽管许多研究小组努力分析这种异质性,但很少有人关注癌细胞利用其他无法使用的底物作为肿瘤发展的燃料。在葡萄糖的两种立体异构体 D-葡萄糖而非 L-葡萄糖中,D-葡萄糖的镜像异构体在自然界中大量存在。 D-葡萄糖是人体通过有氧呼吸提供能量的主要来源。然而,关于检查癌细胞吸收 L-葡萄糖能力的体外和体内研究的数据很少。
目的:本小型综述旨在提供基于体外和体内研究的 L-葡萄糖在癌症诊断中的作用的当前文献数据。
方法:搜索 MEDLINE、EMBASE 和 Cochrane 图书馆,这些图书馆对英语数据库中的文章有限制,以检索可用数据。
结果:关于检查癌细胞吸收 L-葡萄糖能力的体外和体内研究的文献数据有限。迄今为止的研究工作表明,荧光检测器与 L-葡萄糖分子的结合产生了一种荧光探针,该探针被恶性癌细胞特异性吸收,从而为它们的检测提供了一种独特的方法。
葡萄糖荧光探针可以成为癌细胞可视化和表征的有用工具。有必要对 L-葡萄糖在癌症中的潜在生物学作用进行更多研究。
关键词: 癌细胞、D-葡萄糖、L-葡萄糖、D-葡萄糖摄取、放射性标记探针、荧光探针、体外研究、体内研究。
Current Medicinal Chemistry
Title:The Use of L-Glucose in Cancer Diagnosis: Results from In Vitro and In Vivo Studies
Volume: 28 Issue: 30
关键词: 癌细胞、D-葡萄糖、L-葡萄糖、D-葡萄糖摄取、放射性标记探针、荧光探针、体外研究、体内研究。
摘要:
Background: Cancer cells are characterized by metabolic heterogeneity. Although many research groups make efforts to analyze this heterogeneity, little attention has been paid to cancer cells utilizing otherwise unusable substrates as fuel for tumor development. Of the two stereoisomers of glucose, D-glucose but not L-glucose, the mirror image isomer of D-glucose is abundantly found in nature. D-glucose is the human body's key source of energy through aerobic respiration. However, data from in vitro and in vivo studies examining the ability of cancer cells to take up L-glucose are scarce.
Objectives: The present mini-review aims to present current literature data on the role of L-glucose in cancer diagnosis based on in vitro and in vivo studies.
Methods: The MEDLINE, EMBASE, and the Cochrane Library with restrictions to articles in English language databases were searched to retrieve available data.
Results: There are limited data in the literature regarding in vitro and in vivo studies that examined the ability of cancer cells to take up L-glucose. Research work so far has shown that that the binding of a fluorescent detector to an L-glucose molecule produced a fluorescent probe that was specifically taken up by malignant cancer cells, thus providing a unique method for their detection.
Conclusion: Given that L-glucose is taken up by cancer cells, L-glucose fluorescent probes can be a useful tool for visualization and characterization of cancer cells. More research on the potential biologic effects of L-glucose in cancer is necessary.
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Cite this article as:
The Use of L-Glucose in Cancer Diagnosis: Results from In Vitro and In Vivo Studies, Current Medicinal Chemistry 2021; 28 (30) . https://dx.doi.org/10.2174/0929867328666210311112240
DOI https://dx.doi.org/10.2174/0929867328666210311112240 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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