Title:Advances in Stem Cells Transplantation for the Therapy of Parkinson’s Disease
Volume: 16
Issue: 8
Author(s): Xiansi Zeng, Wenshuo Geng, Jinjing Jia*Zhanqi Wang
Affiliation:
- Department of Physiology, Jiaxing University Medical College, Jiaxing 314001,China
Keywords:
Parkinson's disease, stem cells, cell therapy, neurodegenerative, substantia nigra pars compacta, striatum.
Abstract: Parkinson’s disease (PD) is a common neurodegenerative disease and is a major culprit
that harms the health of elderly people. The main pathological feature is the progressive loss of dopaminergic
neurons in the substantia nigra pars compacta of the midbrain. The current mainstream
therapeutic strategies include surgical treatment and medicine substitute therapy. However, these
treatment methods sometimes have limitations. Subsequently, the treatment with stem cells (SCs)
transplantation has been gradually established. SCs is a kind of cell with self-renewal ability and
multi-directional differentiation potential. Transplantation of SCs, including embryonic stem cells,
adult stem cells (neural stem cells and mesenchymal stem cells) and induced pluripotent stem cells,
have the ability to mediate nerve regeneration and restoration within the lesioned midbrain tissue,
bringing hope for the treatment of PD. In this paper, we summarize the progress in therapeutic
strategies of different types of SCs in PD treatment, with an emphasis on the advantages and limitations.
