Title:Edema-mass Ratio Based On Magnetic Resonance Imaging As A Preoperative Diagnostic Factor For Posterior Fossa Metastasis
Volume: 17
Author(s): Ismail Kaya*, Ilker Deniz Cingoz *, Merve Gursoy , Murat Atar, Gonul Guvenc , Inan Uzunoglu , Meryem Cansu Sahin and Nurullah Yuceer
Affiliation:
- Department of Neurosurgery, Kutahya Health Science University, Medical Faculty, Kutahya,Turkey
- Department of Neurosurgery, Kutahya Health Science University, Medical Faculty, Kutahya,Turkey
Keywords:
Edema, magnetic resonance imaging, metastasis, posterior fossa, prognostic factor, survival.
Abstract:
Background: Peritumoral edema of primary brain tumors is an important cause of morbidity
and mortality. The number of studies currently available on the prognostic role of peritumoral
brain edema in the posterior fossa is extremely limited.
Objective: Based on the known importance of magnetic resonance imaging in diagnosing supratentorial
metastases, this study aimed to investigate the effects of peritumoral edema on survival of patients
with posterior fossa metastases and the preoperative diagnostic value of MRI.
Methods: Edema and mass volumes of 49 patients with posterior fossa metastasis, who underwent
surgery during 2012–2016, were measured using magnetic resonance imaging. The edema/mass indices
were retrospectively calculated and interpreted by evaluating the demographic, clinical, and
survival data.
Results: The study consisted of 32 (65.3%) male and 17 (34.7%) female participants, with the
mean age ± standard deviation of 47.25±29.25 (17–81) years. Among the 49 patients with posterior
fossa metastases, 34 (69.4%) had carcinoma, while 15 (30.6%) had non-carcinoma metastases. The
edema/mass indices of patients with carcinoma and non-carcinoma metastases were found to be
14.55±9.64 and 1.34±1.08, respectively, and the difference was statistically significant (p<0.001).
The mean survival of patients with carcinoma and non-carcinoma metastases was found to be
642±11.52 days and 726±9.32 days, respectively; however, this difference was not statistically significant
(p=0.787).
Conclusion: The edema/mass ratio was found to be a significant diagnostic factor for the prediction
of posterior fossa metastases. Further detailed studies are warranted to investigate the effect of
edema/mass ratio on survival rate.
