Title:Alzheimer’s Disease: Pathogenesis and Therapeutic Interventions
Volume: 15
Issue: 1
Author(s): John O. Ogbodo, Chinazom P. Agbo*, Ugochi O. Njoku, Martins O. Ogugofor, Simeon I. Egba, Stella A. Ihim, Adaeze C. Echezona, Kenneth C. Brendan, Aman B. Upaganlawar and Chandrashekhar D. Upasani
Affiliation:
- Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria
Keywords:
Alzheimer’s disease, dementia, environmental pollutants, diet, nanoformulations, neurotransmitters, medicinal plants.
Abstract: Background: Alzheimer’s Disease (AD) is the most common cause of dementia. Genetics,
excessive exposure to environmental pollutants, as well as unhealthy lifestyle practices are often
linked to the development of AD. No therapeutic approach has achieved complete success in
treating AD; however, early detection and management with appropriate drugs are key to improving
prognosis.
Interventions: The pathogenesis of AD was extensively discussed in order to understand the reasons
for the interventions suggested. The interventions reviewed include the use of different therapeutic
agents and approaches, gene therapy, adherence to healthy dietary plans (Mediterranean diet,
Okinawan diet and MIND diet), as well as the use of medicinal plants. The potential of nanotechnology
as a multidisciplinary and interdisciplinary approach in the design of nano-formulations
of AD drugs and the use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic
tools for early detection of Alzheimer’s disease were also discussed.
