摘要
炎症小体的研究主要集中在神经组织,特别是受损组织。目前大多数神经学文献都涉及到利用星形胶质细胞的体内和体外研究,因为星形胶质细胞表达细胞骨架胶质纤维酸性蛋白(GFAP),这是神经病理学疾病的标志。研究表明,星形胶质细胞通过反应性星形胶质增生对所有形式的神经损伤或疾病都有反应。此外,科学家们一致认为炎症小体在神经炎症中发挥着重要作用。本文综述了炎性小体生物学的最新进展,描述了目前对炎性小体如何在大脑中触发的理解,并总结了炎性小体NLR在流行神经系统疾病中的相关性的文献。
关键词: 星形胶质细胞、炎性小体、神经系统疾病、炎症、信号传导、NOD-样受体。
Current Medicinal Chemistry
Title:Astrocytes and Inflammasome: A Possible Crosstalk in Neurological Diseases
Volume: 28 Issue: 24
关键词: 星形胶质细胞、炎性小体、神经系统疾病、炎症、信号传导、NOD-样受体。
摘要: Inflammasome research has primarily focused on neurological tissue, particularly on damaged tissue. Most current neurological literature involves in vivo and in vitro studies utilizing astroglia, as astroglia express the cytoskeletal glial fibrillary acidic protein (GFAP), which is used as a hallmark of neuropathological disorders. Research suggests that astrocytes respond to all forms of neurological damage or disease through reactive astrogliosis. Additionally, there is a consensus among scientists that inflammasomes play an important role in neuroinflammation. This review focuses on the latest developments in inflammasome biology, describing the current understanding of how inflammasomes can be triggered in the brain and summarizing the literature on the relevance of inflammasome NLR in prevalent neurological diseases.
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Cite this article as:
Astrocytes and Inflammasome: A Possible Crosstalk in Neurological Diseases, Current Medicinal Chemistry 2021; 28 (24) . https://dx.doi.org/10.2174/0929867328666210301105422
DOI https://dx.doi.org/10.2174/0929867328666210301105422 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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