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摘要
癌症是由一系列不受控制的细胞组成,最终形成肿瘤,对身体机能产生负面影响,诱发其他严重疾病,甚至导致死亡。在过去的几十年里,科学家们付出了巨大的努力来研究癌症。然而,没有有效的诊断和治疗方法。近年来,纳米材料在生物医学领域引起了极大的关注,被广泛用作光学成像探针和癌症治疗的传递系统。在众多的纳米材料中,聚合物纳米粒子因其微米尺寸可调、多功能表面、突出的生物相容性和高载药能力而占据突出地位。高分子纳米材料的这些显着优势比传统纳米材料具有重要意义,已成为一种潜在的癌症治疗方法。在这篇综述中,我们关注聚合物纳米粒子在癌症治疗诊断学中的应用,特别是作为癌症治疗的药物递送系统。本综述概述了基于聚合物纳米颗粒的药物递送系统的合成、应用的进展,并强调了对癌症治疗的评估。
关键词: 聚合物纳米粒子、靶向递送、控释、肿瘤、癌症治疗、恶性肿瘤。
Current Medicinal Chemistry
Title:Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment
Volume: 28 Issue: 31
关键词: 聚合物纳米粒子、靶向递送、控释、肿瘤、癌症治疗、恶性肿瘤。
摘要: Cancer is composed of a series of uncontrollable cells, which finally form tumors to negatively impact the functions of the body and induce other serious diseases, even leading to death. During the last decades, scientists have devoted great efforts to study cancer; however, there are no effective diagnoses and treatments. Nanomaterials have attracted great attention in the biomedical field in recent years, which are widely used as optical imaging probes and delivery systems for cancer therapy. Among the numerous nanomaterials, polymeric nanoparticles occupy a prominent position because of their tunable micro-size, multifunctional surface, prominent biocompatibility and high drug-carrying capacity. These significant advantages of polymeric nanomaterials have significance over the traditional nanomaterials and have become a potential therapy for cancer. In this review, we focus on the applications of polymeric nanoparticles in cancer theranostics, especially as the drug delivery systems for cancer treatment. This review provides an overview on the advancement of synthesis, application of polymeric nanoparticles- based drug delivery systems and highlights the evaluation for cancer therapy.
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Cite this article as:
Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867328666210226143148
DOI https://dx.doi.org/10.2174/0929867328666210226143148 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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