Title:Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts
Volume: 22
Issue: 7
Author(s): Sunchu Harika*, Y. Shravan Kumar*, Y. Madhusudhan Rao, Pavani Sriram and Uma Shankar
Affiliation:
- Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences, Kakatiya University, Telangana, Warangal 506002,India
- Department of Pharmaceutics, Vaagdevi College of Pharmacy Affiliated by Kakatiya University, Magnificent Cosmo Cosmoceuticals, Telangana, Warangal 506002,India
Keywords:
Intra pocket drug delivery, sustained-release, periodontal disease, pocket depth, enhanced bioavailability, ethylcellulose, anaerobic
bacteria, minimum inhibitory concentration.
Abstract:
Aim & Background: Ornidazole is an antimicrobial drug used to treat certain types of vaginal, urinary
tract, and interstitial infections. The study aims to formulate and evaluate the dental inserts by using a drug candidate
to sustained drug release to improve patient compliance, reduce dosing frequency, reduce the risk of dose dumping,
and avoid the first-pass metabolism. They have better therapeutic efficacy and fewer side effects.
Methods: The dental inserts were prepared using various polymers alone and in combination with the different ratios
of polymers. The evaluation parameters like thickness, drug content, content uniformity, moisture reuptake, weight
variation, swelling studies, and erosion studies of the optimized inserts were studied. The in-vivo studies were conducted
to determine the reduction of pocket depth in human volunteers.
Results: The system containing ethylcellulose and hydroxyl methyl propyl cellulose K100M (4:1) formulation F6
was optimized because drug release was sustained up to 120 hrs concerning other formulations. Optimized formulation
followed first-order kinetics and Peppas release kinetics via fickian diffusion. There was no swelling, itching,
irritation, and no reduction in the pocket depth in in-vivo studies.
Conclusion: The study concluded that dental inserts could extend the release of Ornidazole for many hours and also
enhance bioavailability. Furthermore, they also help in avoiding the first-pass effect. In vivo studies’ observations
showed no itching, irritation, swelling, and pocket-depth reduction.
