Abstract
Over the years, the development of bioactive heterocycles has aroused the interest of the scientific community, because in general, these heterocycles are strategic in maintaining life. Research into bioactive heterocycles is associated with the development of methods of synthesis and the biological evaluation of different nuclei. In consequence, there has been a growing interest in the nucleus of fused pyrimidine, which has diversified pharmacological activities, including diuretic, antimicrobial, antifolate, tyrosine kinase, anti-inflammatory, anticancer, anthelminthic, and antiviral activities. This review focuses on describing a diverse set of structures derived from pyrimido[4,5-d]pyrimidines and contemplates the main bioactivities of these nuclei.
Keywords: Pyrimidopyrimidine, fused pyrimidines, pyrimidines, heterocycles, antimicrobial, diuretic, antifolate.
Mini-Reviews in Medicinal Chemistry
Title:Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines
Volume: 21 Issue: 15
Author(s): Jacqueline Santos Cruz *Alcino Palermo de Aguiar
Affiliation:
- Department of Chemistry, Military Institute of Engineering, Rio de Janeiro,Brazil
Keywords: Pyrimidopyrimidine, fused pyrimidines, pyrimidines, heterocycles, antimicrobial, diuretic, antifolate.
Abstract: Over the years, the development of bioactive heterocycles has aroused the interest of the scientific community, because in general, these heterocycles are strategic in maintaining life. Research into bioactive heterocycles is associated with the development of methods of synthesis and the biological evaluation of different nuclei. In consequence, there has been a growing interest in the nucleus of fused pyrimidine, which has diversified pharmacological activities, including diuretic, antimicrobial, antifolate, tyrosine kinase, anti-inflammatory, anticancer, anthelminthic, and antiviral activities. This review focuses on describing a diverse set of structures derived from pyrimido[4,5-d]pyrimidines and contemplates the main bioactivities of these nuclei.
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Cite this article as:
Cruz Santos Jacqueline *, de Aguiar Palermo Alcino , Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines, Mini-Reviews in Medicinal Chemistry 2021; 21 (15) . https://dx.doi.org/10.2174/1389557521666210219160115
DOI https://dx.doi.org/10.2174/1389557521666210219160115 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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