Title:Antidyslipidemic Capacity of Cleome arabica (L.) in Streptozotocin-Induced Diabetic Rats
Volume: 20
Issue: 1
Author(s): Ayoub Amssayef and Mohamed Eddouks*
Affiliation:
- Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509,
Boutalamine, 52000, Errachidia, Morocco
Keywords:
Antidyslipidemic, antiatherogenic, Cleome arabica, lipid abnormalities, phytochemical compounds, medicinal plant.
Abstract:
Aims: The aim of the study was to assess the effect of Cleome arabica on lipid
metabolism.
Background: Cleome arabica (L.) is a medicinal plant used traditionally by the population of
North Africa for managing diabetes mellitus.
Objective: This study was designed to evaluate the antidyslipidemic and antiatherogenic capacities
of Cleome arabica (L.) in normal and streptozotocin(STZ)-induced diabetic rats.
Methods: The hypolipidemic, antihyperglycemic and antiatherogenic effects of oral administration
of the aqueous extract of Cleome arabica (CAAE) (100 mg/kg) were evaluated in normal and diabetic
rats. In addition, the quantification of polyphenols, flavonoids and tannins as well as the antioxidant
activity were performed.
Results: The results showed that the extract (CAAE) revealed an antidyslipidemic action by attenuating
plasma levels of Total Cholesterol (TC), Triglycerides (TGs), Low-Density Lipoprotein
cholesterol (LDL-c), Very low-density lipoprotein cholesterol (VLDL-c) and glucose. Additionally,
CAAE exhibited a potent antiatherogenic activity by reducing Atherogenic Coefficient (AC),
Castelli’s Risk index-I (cri-I), and Castelli’s Risk Index-II (CRI-II). Furthermore, the findings indicated
that CAAE is abundant with polyphenols, flavonoids and tannins, and exhibited an important
antioxidant capacity.
Conclusion: The study demonstrates that aqueous Cleome arabica extract was able to ameliorate
lipid abnormalities associated with diabetes mellitus. This pharmacological activity might be due
to the antioxidant capacities of phytochemical compounds.
