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Mini-Reviews in Organic Chemistry

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ISSN (Online): 1875-6298

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Mini-Review Article

Synthetic and Reactions Routes to Tetrahydrothieno[3,2-b]Quinoline Derivatives (Part IV)

Author(s): Ameen A. Abu-Hashem*, Ahmed A. M. Abdelgawad, Hoda A. R. Hussein and Moustafa A. Gouda*

Volume 19, Issue 1, 2022

Published on: 18 February, 2021

Page: [74 - 91] Pages: 18

DOI: 10.2174/1570193X18666210218212719

Abstract

This review describes the synthesis and chemical reactivity of tetrahydrothieno[3,2-b] quinoline derivatives through many reagents such as; 1, 2-dihydropyridine-3-carbonitrile; 1,6-dihydropyrimidine- 5-carbonitrile; 2,3-dihydropyridazine-4-carbonitrile; 3-amino-thiophene-2-carboxylate; 3- amino-thiophene-2-carbonitrile; 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbo- nitrile; 2-(3-bromo-1- iodoisoquinolin-8-yl) benzonitrile and 3-mercapto-benzo[g]quinolin-4(1H)-one derivatives. The synthesis of tetrahydrothieno [3, 2-b] quinoline derivatives was explained through the following chemical reactions: Aldol condensation, alkylation, cyclocondensation, dehydration, chlorination, Wolff-Kishner reduction, acylation, Friedlander reaction and intramolecular cyclization

Keywords: Pyridine-3-carbonitrile, pyrimidine-5-carbonitrile, 3-aminothiophene-2-carbonitrile, iodoisoquinolines, mercaptobenzoquinolinones, synthesis, reactivity

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