Title:Post Translational Modification and Its Pathologic Association in Rheumatoid Arthritis: A Brief Perspective
Volume: 22
Issue: 7
Author(s): Vishnupreetha Vasudevan, Prachi Agnihotri and Sagarika Biswas*
Affiliation:
- Council of Industrial Research (CSIR)-Institute of Genomics and Integrative Biology, Mall Road, Delhi University Campus, Delhi, 110007,India
Keywords:
Post-translational modification, Rheumatoid arthritis, inflammation, marker, pathogenesis, anticitrullinatedncyclic
peptide.
Abstract: Post Translational Modification (PTM) is a process in which covalent addition of functional
groups on protein occurs to maintain their structure, function and stability. Every PTM process
in our living system occurs to enhance the functional diversity of a protein. But sometimes, it occurs
without any regulation and that might lead to autoimmunity. Rheumatoid arthritis (RA) is one such
chronic, inflammatory, autoimmune disease that affects the joints. Proper treatment can make the
symptoms manageable for RA, but it is not curable. Delayed diagnosis of RA can cause severe bone
pain, stiffness, inflammation, redness in joints and affect other parts of the body such as the liver,
kidney, etc. Early diagnosis of RA is necessary to manage the aggressive symptoms. Currently,
Rheumatoid factor (RF) and anti-citrullinated cyclic peptide (Anti-CCP) are considered as biomarkers
to diagnose RA. Besides citrullination, several other PTMs are also involved in the generation of
autoantibodies, such as carbamylation, glycosylation, glycation, acetylation, ubiquitination, proteolysis,
phosphorylation, and lipidation. The aim of this review is to elucidate several changes in the
form, nature, and function of PTMs in RA. This review will give a recent overview on the role of
PTMs in the pathogenesis of RA with a focus on the post-translational modifications.
