![conference banner](/images/conference-banner.jpeg)
摘要
背景:转录组分析显示,哺乳动物细胞中存在大量长链非编码RNA(lncRNAs)。许多lncRNAs以发育、分化和疾病特异性的方式表达,表明它们作为细胞调节剂的重要性。一些核lncRNAs与特定的基因组位点结合,或离自身转录位点近或远,并以顺式或反式的方式调控基因表达。这些lncRNAs招募表观遗传因子,包括DNA甲基转移酶和组蛋白修饰复合物,并介导3D基因组结构和核结构域。lncRNAs现在被认为是表观遗传调控的新兴成员。lncRNAs在各种类型的癌症中都是失调的,并作为致癌或肿瘤抑制因子。它们涉及几乎所有的癌症特征,是潜在的诊断标记和治疗靶点。目的:在这篇综述中,我们综述了几个具有代表性的lncRNAs,并概述了目前lncRNAs参与表观遗传调控和参与癌症发展的机制。
关键词: 长链非编码RNA,表观遗传学,癌症,组蛋白修饰,DNA甲基化,ELEANORS,染色质。
Current Medicinal Chemistry
Title:Nuclear Long Non-Coding RNAs as Epigenetic Regulators in Cancer
Volume: 28 Issue: 25
关键词: 长链非编码RNA,表观遗传学,癌症,组蛋白修饰,DNA甲基化,ELEANORS,染色质。
摘要:
Background: Transcriptome analyses have revealed the presence of numerous long non-coding RNAs (lncRNAs) in mammalian cells. Many lncRNAs are expressed in development-, differentiation-, and disease-specific manners, suggesting their importance as cell regulators. Some nuclear lncRNAs are bound to specific genomic loci, either near or distant from their own transcription sites, and regulate gene expression in cis or trans. These lncRNAs recruit epigenetic factors, including the DNA methyl transferase and histone modification complex, and mediate both the 3D genome structure and nuclear domains. LncRNAs are now considered as an emerging member of epigenetic regulators. LncRNAs are dysregulated in various types of cancer and act as either oncogenic or tumor- suppressing factors. They are involved in virtually all of the cancer hallmarks and are potential diagnostic markers and therapeutic targets.
Objective: In this review, we describe several representative lncRNAs and provide a current overview of the mechanisms by which lncRNAs participate in epigenetic regulation and contribute to cancer development.
Export Options
About this article
Cite this article as:
Nuclear Long Non-Coding RNAs as Epigenetic Regulators in Cancer, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666210215114506
DOI https://dx.doi.org/10.2174/0929867328666210215114506 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Impact of Epigenetic Dietary Components on Cancer through Histone Modifications
Current Medicinal Chemistry Identification and Preclinical Evaluation of SC144, a Novel Pyrroloquinoxaline Derivative with Broad-Spectrum Anticancer Activity
Mini-Reviews in Medicinal Chemistry Innovative Formulations for the Controlled and Site-specific Delivery of Antiinflammatory Drugs
Current Pharmaceutical Design The Engaged Role of Tumor Microenvironment in Cancer Metabolism: Focusing on Cancer-Associated Fibroblast and Exosome Mediators
Anti-Cancer Agents in Medicinal Chemistry Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development?
Current Topics in Medicinal Chemistry Eph Receptor Tyrosine Kinases in Tumor and Tumor Microenvironment
Current Pharmaceutical Design Subject Index to Volume 4
Current Drug Metabolism Development of Highly Efficient KinExA Immunosensor-Based Assay for the Measurement of Carcinoembryonic Antigen in Serum
Current Analytical Chemistry The Efficacy and Mechanism of Proteasome Inhibitors in Solid Tumor Treatment
Recent Patents on Anti-Cancer Drug Discovery Bioactive N-Phenylimidazole Derivatives
Current Chemical Biology Preventive Effect of Soybean on Brain Aging and Amyloid-β Accumulation: Comprehensive Analysis of Brain Gene Expression
Recent Patents on Food, Nutrition & Agriculture Is it Possible to Reduce the Incident of Colorectal Cancer by Modifying Diet and Lifestyle?
Current Cancer Therapy Reviews Antisense Strategies in Therapy of Gliomas
Current Signal Transduction Therapy Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment
Recent Patents on Anti-Cancer Drug Discovery Natriuretic Peptides in Gastrointestinal Cancer: Biomarkers and Potential Therapeutic Targets
Current Drug Research Reviews Current and Proposed Biomarkers of Anthracycline Cardiotoxicity in Cancer: Emerging Opportunities in Oxidative Damage and Autophagy
Current Molecular Medicine Anticancer Vitamin K3 Analogs: A Review
Anti-Cancer Agents in Medicinal Chemistry Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression
Anti-Cancer Agents in Medicinal Chemistry Monoclonal Antibody “Gold Rush”
Current Medicinal Chemistry Withdrawal Notice: Investigation of the Use of Neural Networks for Diagnosing Breast Cancer on Mammograms
Current Medical Imaging