摘要
核碱基代表生物活性分子(包括合成和天然产物)中的关键结构基序。 对核碱基进行的分子修饰或从天然来源中分离出来的分子修饰正在被广泛研究,以开发具有更高效力的药物,用于治疗不同疾病,如癌症,以及病毒和细菌感染。 这篇综述文章重点介绍了过去 20 年(2000-2020 年)的核碱基类似物药物发展。 讨论了核碱基及其类似物的各种药理学和药用方面。 还强调了当前的状态和限制。
关键词: 核碱基、药物发现、腺嘌呤、胸腺嘧啶、胞嘧啶、鸟嘌呤、尿嘧啶。
Current Medicinal Chemistry
Title:From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates
Volume: 28 Issue: 34
关键词: 核碱基、药物发现、腺嘌呤、胸腺嘧啶、胞嘧啶、鸟嘌呤、尿嘧啶。
摘要: Nucleobases represent key structural motifs in biologically active molecules, including synthetic and natural products. Molecular modifications made on nucleobases or their isolation from natural sources are being widely investigated for the development of drugs with improved potency for the treatment of different diseases, such as cancer, as well as viral and bacterial infections. This review article focuses on the nucleobase analogue drug developments of the past 20 years (2000-2020). Various pharmacological and medicinal aspects of nucleobases and their analogues are discussed. The current state and limitations are also highlighted.
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From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates, Current Medicinal Chemistry 2021; 28 (34) . https://dx.doi.org/10.2174/0929867328666210215113828
DOI https://dx.doi.org/10.2174/0929867328666210215113828 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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