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Abstract
An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one-pot three-component reaction of aldehydes, trimethyl allylsilane, and NH4SCN in the presence of BF3.Et2O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).
Keywords: Aldehydes, allyl trimethylsilane, lewis acid, prins cyclization, thiocyanatotetrahydropyran, one-pot reaction.
Current Organocatalysis
Title:An Efficient One-pot Stereoselective Synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans
Volume: 8 Issue: 3
Author(s): Chithaluri Sudhakar*Pochamoni Ramudu
Affiliation:
- Department of Chemistry, GITAM School of Science, GITAM Deemed to be University, Telangana-502 329,India
Keywords: Aldehydes, allyl trimethylsilane, lewis acid, prins cyclization, thiocyanatotetrahydropyran, one-pot reaction.
Abstract: An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one-pot three-component reaction of aldehydes, trimethyl allylsilane, and NH4SCN in the presence of BF3.Et2O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).
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Cite this article as:
Sudhakar Chithaluri *, Ramudu Pochamoni , An Efficient One-pot Stereoselective Synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans, Current Organocatalysis 2021; 8 (3) . https://dx.doi.org/10.2174/2213337208666210212121506
DOI https://dx.doi.org/10.2174/2213337208666210212121506 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
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