Title:Highlighting Exosomes’ Function in Cardiovascular Diseases
Volume: 18
Issue: 3
Author(s): Sidhi Laksono*, Budhi Setianto, Ananta Siddhi Prawara and Bambang Dwiputra
Affiliation:
- Department of Cardiology and Vascular Medicine, RSUD Pasar Rebo, Faculty of Medicine, Universitas Muhammadiyah
Prof. DR. Hamka, Tangerang, Indonesia
Keywords:
Diagnostic, exosomes, prognostic role, therapeutic role, endothelial cells, cardiovascular disease.
Abstract: Exosomes, as one of the extracellular vesicles’ subgroups, played an important role in
the cell to cell communication. The cargos and surface protein of exosomes have been known to affect
the cardiovascular system both positively and negatively in chronic heart failure, ischemic
heart disease, and atherosclerosis. There have been several exosomes that emerged as potential diagnostic
and prognostic markers in cardiovascular patients. However, the conditions affecting the
patients and the method of isolation should be considered to create a standardized normal value of
the exosomes and the components. CPC-derived exosomes, ADSCs-derived exosomes, and telocyte-
derived exosomes have been proven to be capable of acting as a therapeutic agent in myocardial
infarction models. Exosomes have the potential to become a diagnostic marker, prognostic
marker, and therapeutic agent in cardiovascular diseases.