Title:Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions
Volume: 16
Issue: 6
Author(s): Fatima Zriek, John A. Di Battista and Nada Alaaeddine*
Affiliation:
- Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut,Lebanon
Keywords:
Mesenchymal stromal cells, secretome, conditioned medium, inflammation, regeneration, neurodegenerative diseases.
Abstract: Mesenchymal stromal cells (MSCs) have emerged as a modern development in therapeutics
for a wide variety of diseases. Secreted paracrine factors constitute the principal components
harboring the restorative promise of MSCs. Recent studies demonstrate that MSC-derived secretomes
are composed of several molecules targeting a variety of biological processes that impact tissue
repair, growth and immunomodulation. Indeed, secretomes interact with immune cells, activating
regulatory anti-inflammatory phenotypes. In this review, we discuss the action of MSC-derived
secretomes in promoting tissue regeneration, opposing the inflammatory response in context-specific
cases, and treating neurodegenerative diseases, resulting from chronic neuroinflammation.
