Title:An Alternative “Trojan Horse” Hypothesis for COVID-19: Immune Deficiency
of IL-10 and SARS-CoV-2 Biology
Volume: 22
Issue: 1
Author(s): Mario Giosuè Balzanelli, Pietro Distratis, Sergey K. Aityan, Felice Amatulli, Orazio Catucci, Angelo Cefalo, Antonia De Michele, Gianna Dipalma, Francesco Inchingolo, Rita Lazzaro, Kieu Cao Diem Nguyen, Davide Palazzo, Marilina Tampoia, Van Hung Pham, Luigi Santacroce*Ciro Gargiulo Isacco
Affiliation:
- Department of Interdisciplinary Medicine, Microbiology and Virology Unit, University
Hospital of Bari, Bari70124, Italy
Keywords:
COVID-19, SARS-CoV-2, arterial blood gas (ABG), IL-10, IL-6, TNF-α, bronchial-alveolar lavage fluid (BALF).
Abstract: Abstract: The coronavirus disease 2019 (COVID-19) pandemic has been a challenge for emergency
care units worldwide due to the large numbers of patients, the scarcity of information, the medical
resources, and the uncertainty regarding the disease's etiology and pathogenesis. The transmission
of the virus and a probable post-pandemic of SARS-CoV-2 will depend on how deep this disease,
the duration of immunity and the degree of cross immunity between SARS-CoV-2 and other
pathogens either bacteria or fungi can be understood. Most mortalities have been related to an atypical
pneumonia consisted of a sudden worsening of general condition of the admitted positive
COVID-19 patients. The severe thromboembolism, often characterized by violent pulmonary and
systemic complications, have been described with a blend of inflammatory-infectious patterns that
rapidly shifted into a typical systemic inflammatory response syndrome (SIRS) or into an acute respiratory
distress syndrome (ARDS) that eventually concluded into a multi-organ failure (MOF) and
death. The fatality rate reported in our Covid-19 structure, SG Moscati Hospital of Taranto
province in Italy, was higher in elderly male people with preexisting chronic pulmonary disease
(COPD), patients with cancer and preexisting cardio-vascular diseases (CVD). We assumed a different
theoretical position to clarify the higher mortality seen among those patients that was not as
obvious as it appeared, we thus offered different pathophysiological picture that could help to recent
solutions in therapy and prevention.
