Title:Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity
Volume: 21
Issue: 17
Author(s): Priyanka Joshi, Sushil Joshi, Deepak Semwal, Akansha Bisht, Sarvesh Paliwal, Jaya Dwivedi and Swapnil Sharma*
Affiliation:
- Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan,India
Keywords:
Curcumin, cancer, phytochemistry, molecular pathways, apoptosis, curcuma longa.
Abstract: Curcuma longa has been mentioned in the Indian system of medicine for the management
of a wide range of diseases. C. longa and its metabolites like curcumin, ar-turmerone, methylcurcumin,
demethoxy-curcumin, and bisdemethoxycurcumin have also been reported to be beneficial
in various types of cancer. Curcumin elicits anticancer properties chiefly by triggering apoptotic
pathways in cancer cells. The properties are facilitated through diverse signaling pathways viz. pathways
mediated by NF-kB, WNT/β-catenin pathway COX-2, LOX, STAT3, prostaglandin E2, phosphorylase
kinase, VEGF, AKT, AP1, STAT3, PI3K, Akt, mTOR, ERK5, AP-1, TGF-b, PPARc,
EBPa, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4, etc. The present article
highlights curcumin biosynthesis, phytochemistry and diverse molecular pathways involved in regulating
several types of secondary messengers to exhibit anticancer activity in almost all the forms of
cancer.
