Title:Interactions between Ketamine and Magnesium for the Treatment of Pain: Current State of the Art
Volume: 20
Issue: 5
Author(s): Katarina S. Vujović*, Sonja Vučković, Radan Stojanović, Nevena Divac, Branislava Medić, Aleksandar Vujović, Dragana Srebro and Milica Prostran
Affiliation:
- Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade,Serbia
Keywords:
NMDA antagonist, pain, ketamine, magnesium, interaction, animals, humans.
Abstract:
Background: Over the past three decades, NMDA-receptor antagonists have been
shown to be efficient drugs for treating pain, particularly pain resistant to conventional analgesics.
Emphasis will be on the old-new drugs, ketamine and magnesium, and their combination as a novel
approach for treating chronic pain.
Methods: The MEDLINE database was searched via PubMed for articles that were published up to
March 1, 2020, with the keywords ‘ketamine’, ‘magnesium’, and ‘pain’ (in the title/abstract).
Results: Studies in animals, as well as humans, have shown that interactions of ketamine and magnesium
can be additive, antagonistic, and synergistic. These discrepancies might be due to differences
in magnesium and ketamine dosage, administration times, and the chronological order of
drug administration. Different kinds of pain can also be the source of divergent results.
Conclusion: This review explains why studies performed with a combination of ketamine and magnesium
have given inconsistent results. Because of the lack of efficacy of drugs available for pain,
ketamine and magnesium in combination provide a novel therapeutic approach that needs to be
standardized with a suitable dosing regimen, including the chronological order of drug administration.
