Title:Chemotherapeutics for Acute Erythroid Leukemia: Research, Present and Future
Volume: 21
Issue: 10
关键词:
急性红细胞白血病、急性髓细胞白血病、化疗药物、红细胞分化、GATA-1、GATA-2、Gfi1b、EKLF、EPO 相关通路。
摘要: Acute erythroid leukemia (AEL) is a subtype of acute myeloid leukemia (AML)
with features such as accumulation of maturation-arrested erythroblasts. Compared with
AML, the progression of AEL is faster and the prognosis to available therapy is worse.
However, its categorization is still being updated and the pathophysiology of AEL is still
under research, making diagnosis and chemotherapy challenging for physicians. To
achieve better outcomes, therapies should be optimized and new drugs should be
developed. In this review, we summarize current strategies of diagnosis and therapies of
AEL, and discuss prospective targets for chemotherapeutic agents based on the
biological characteristics of AEL neoplastic cells as well as transcriptional factors and
pathways related to erythroid differentiation.
