Title:A Review on Exploring Better Safety Prospects in Managing Cancer using Liposomal Combinations of Food Bioactive Compounds and Anticancer Drugs: Combisomes
Volume: 18
Issue: 8
Author(s): Akhilesh Dubey, Ravi G. Shriram and Sally A. El-Zahaby*
Affiliation:
- Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria,Egypt
Keywords:
Cancer, chemotherapy, liposomes, combisome, food bioactive compounds, probiotics.
Abstract: Nowadays, cancer is one of the deadliest diseases affecting an annually enormous number
of people. Around 9.6 million people had died from different cancer types in 2018. Chemotherapy
is considered to be a mainline treatment, and systemic administration of a single anticancer
agent is also considered a vital clinical debacle of chemotherapy in cancer management. The formulators
have been focusing currently onto procuring maximum benefit with the lowest aftereffects
and maximum safety and efficacy for the patients undergoing chemotherapy. This review offers a
perspective on the future developments of encapsulating food bioactive compounds with anticancer
agents in a multifunctional single nanoliposomal delivery system. In the last decade, the paradigm
shift was seen in formulating drug delivery systems for cancer treatment. Currently, food bioactive
compounds are being taken as a hot subject by researchers, especially for the treatment of cancer
owing to both preventative and curative quality. This review collects the utilization of liposomes in
the delivery of anticancer drugs by encapsulating with food bioactive compounds by the oral administration.
The authors coined the name of this combination is “Combisomes” as a fourth generation
liposomes. Authors opine that “Combisomes” can tackle cancer minimizing side effects encountered
from the usual anticancer agents. “Combisomes” will purvey a safe platform for the delivery
of food bioactive compounds and anticancer agents for managing cancer with better safety
prospects.
