Title:Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat
Volume: 22
Issue: 10
Author(s): Raghuvir Keni, Abinitha Sekhar, Karthik Gourishetti, Pawan G. Nayak, Manas Kinra, Nitesh Kumar, Rekha R. Shenoy, Anoop Kishore and Krishnadas Nandakumar*
Affiliation:
- Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal – 576104, Karnataka,India
Keywords:
Statins, diabetes, metabolic syndrome, hypercholesterolemia, drug-induced diabetes, cholesterol.
Abstract: Statins have transformed the treatment of cardiovascular diseases through primary and
secondary prevention of events. Despite the success of statin's management of cardiovascular conditions,
certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to
induce diabetes. The risk further increases with intensive statin therapy or in patients with diabetes.
A proper mechanism for the induction of the diabetic condition has not yet been determined. The
involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance
has been widely studied and established. The present review provides an update on the recent understanding
of statin-induced diabetes. This covers the origin of statins, their development, possible
mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to
remedy the condition.
