Title:The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery
Volume: 22
Issue: 8
关键词:
纳米粒子、蛋白质电晕、免疫清除、防污、隐身、仿生隐身。
摘要: Nano-drug delivery systems (Nano-DDS) offer powerful advantages in drug delivery
and targeted therapy for diseases. Compared to the traditional drug formulations, Nano-DDS can increase
solubility, biocompatibility, and reduce off-targeted side effects of free drugs. However,
they still have some disadvantages that pose a limitation in reaching their full potential in clinical
use. Protein adsorption in blood, activation of the complement system, and subsequent sequestration
by the mononuclear phagocyte system (MPS) consequently result in nanoparticles (NPs) to be
rapidly cleared from circulation. Therefore, NPs have low drug delivery efficiency. So, it is important
to develop stealth NPs for reducing bio–nano interaction. In this review, we first conclude the
interaction between NPs and biological environments, such as blood proteins and MPS, and factors
influencing each other. Next, we will summarize the new strategies to reduce NPs protein adsorption
and uptake by the MPS based on current knowledge of the bio–nano interaction. Further directions
will also be highlighted for the development of biomimetic stealth nano-delivery systems by
combining targeted strategies for a better therapeutic effect.